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Showing 1 - 9 of 9 Items
Showing 1 - 9 of 9 Items
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Research

Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis

Zwang J, Olliaro PL, Barennes H, Bonnet MMB, Brasseur P,  et al.
2009-08-23 • Malaria Journal
2009-08-23 • Malaria Journal
BACKGROUND: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of...
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Drug resistance in Plasmodium falciparum from the Chittagong Hill Tracts, Bangladesh

van den Broek IVF, van der Wardt S, Talukder L, Chakma S, Brockman A,  et al.
2004-06-01 • Tropical Medicine and International Health
2004-06-01 • Tropical Medicine and International Health
OBJECTIVE: To assess the efficacy of antimalarial treatment and molecular markers of Plasmodium falciparum resistance in the Chittagong Hill Tracts of Bangladesh. METHODS: A total of 203...

Assessing antimalarial efficacy in a time of change to artemisinin-based combination therapies: The role of Médecins Sans Frontières

Guthmann JP, Checchi F, van den Broek IVF, Balkan S, Van Herp M,  et al.
2008-08-05 • PLOS Medicine
2008-08-05 • PLOS Medicine

Chloroquine, sulfadoxine-pyrimethamine and amodiaquine efficacy for the treatment of uncomplicated Plasmodium falciparum malaria in Upper Nile, south Sudan

van den Broek IVF, Gatkoi T, Lowoko B, Nzila A, Ochong E,  et al.
2008-01-31 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2008-01-31 • Transactions of the Royal Society of Tropical Medicine and Hygiene
The current first-line and second-line drugs for Plasmodium falciparum malaria in South Sudan, chloroquine and sulfadoxine-pyrimethamine (SP), were evaluated and compared with amodiaquin...

Geographical distribution of selected and putatively neutral SNPs in Southeast Asian malaria parasites

Anderson TJC, Nair SA, Sudimack D, Williams JT, Mayxay M,  et al.
2005-12-01 • Molecular Biology and Evolution
2005-12-01 • Molecular Biology and Evolution
Loci targeted by directional selection are expected to show elevated geographical population structure relative to neutral loci, and a flurry of recent papers have used this rationale to...

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children

Ashley EA, Pinoges LLP, Turyakira E, Dorsey G, Checchi F,  et al.
2008-08-09 • Malaria Journal
2008-08-09 • Malaria Journal
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with im...

Short report: association between cloroquine and amodiaquine resistance and allelic variation in the Plasmodium falciparum multiple drug Resistance 1 gene and the chloroquine resistance transporter gene in isolates from the upper Nile in Southern Sudan

Ochong E, van den Broek IVF, Keus K, Nzila A
2003-08-01 • American Journal of Tropical Medicine and Hygiene
2003-08-01 • American Journal of Tropical Medicine and Hygiene
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has b...

Artesunate + amodiaquine and artesunate + sulphadoxine-pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine-resistant haplotypes

Swarthout TD, van den Broek IVF, Kayembe G, Montgomery JM, Pota H,  et al.
2006-10-01 • Tropical Medicine and International Health
2006-10-01 • Tropical Medicine and International Health
We undertook a trial of artesunate + amodiaquine (AS + AQ) and artesunate + sulphadoxine-pyrimethamine (AS + SP) in 180 children of age 6-59 months with uncomplicated malaria in Democrat...

Efficacy of chloroquine + sulfadoxine--pyrimethamine, mefloquine + artesunate and artemether + lumefantrine combination therapies to treat Plasmodium falciparum malaria in the Chittagong Hill Tracts, Bangladesh

van den Broek IVF, Maung U, Peters A, Liem L, Kamal M,  et al.
2005-10-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2005-10-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Bangladesh faces growing levels of Plasmodium falciparum resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP). Alternative antimalarial therapies, particularly combination r...