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Showing 1 - 15 of 15 Items
Showing 1 - 15 of 15 Items
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Research

Diagnostic accuracy of the WHO tuberculosis treatment decision algorithms for children with presumptive tuberculosis: An individual participant data meta-analysis

Olbrich L, Larsson L, Dunbar R, Dodd PJ, Palmer M,  et al.
2025-11-18 • PLOS Medicine
2025-11-18 • PLOS Medicine

INTRODUCTION

In 2023, almost 200,000 children under 15 years died from tuberculosis, most without appropriate treatment. Treatment decision algorithms (TDAs), d...

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Protocol
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Research
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Research
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External quality assurance of chest X-ray interpretation to strengthen diagnosis of childhood TB

Melingui B, 
Journal Article
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Research
Journal Article
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Research
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Review

Evaluating the diagnostic accuracy of WHO-recommended treatment decision algorithms for childhood tuberculosis using an individual person dataset: a study protocol

Olbrich L, Larsson L, Dodd P, Palmer M, Nguyen MHTN,  et al.
2025-09-17 • BMJ Open
2025-09-17 • BMJ Open

INTRODUCTION

In 2022, the WHO conditionally recommended the use of treatment decision algorithms (TDAs) for treatment decision-making in children <10 years with...

Centrifuge-free stool processing methods for Xpert MTB/RIF Ultra tuberculosis diagnosis in children in Uganda and Zambia: an observational, prospective, diagnostic accuracy study

Lounnas M, Masama EN, Beneteau S, Kasakwa K, Kaitano R,  et al.
2025-06-01 • Lancet Microbe
2025-06-01 • Lancet Microbe

BACKGROUND

WHO recommends Xpert MTB/RIF Ultra (Ultra) for stool testing for tuberculosis diagnosis in children. Stool processing requires removal of debris and ...

Implementation of digital chest radiography for childhood tuberculosis diagnosis at district hospital level in six high tuberculosis burden and resources limited countries

Melingui BF, Basant J, Taguebue Jv, Massom DM, Leroy Terquem E,  et al.
2024-11-03 • Journal of Tropical Medicine
2024-11-03 • Journal of Tropical Medicine

OBJECTIVES

Chest x‐ray (CXR) plays an important role in childhood tuberculosis (TB) diagnosis, but access to quality CXR remains a major challenge in resource‐l...

Leroy-Terquem E, 
Taguebue J, 
Eap T, 
Borand L, 
et al.
2024-10-01 • IJTLD OPEN
2024-10-01 • IJTLD OPEN

Cost-effectiveness and budget impact of decentralising childhood tuberculosis diagnosis in six high tuberculosis incidence countries: a mathematical modelling study

d’Elbée M, Harker M, Mafirakureva N, Nanfuka M, Nguyet MHTN,  et al.
2024-03-21 • eClinicalMedicine
2024-03-21 • eClinicalMedicine

Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study

Wobudeya E, Nanfuka M, Ton Nu Nguyet MH, Taguebue JV, Moh R,  et al.
2024-03-21 • ACG Case Reports Journal
2024-03-21 • ACG Case Reports Journal
BACKGROUND
Childhood tuberculosis (TB) remains underdiagnosed largely because of limited awareness and poor access to all or any of specimen collection, molecular testing, clinical e...

Evaluation of a short training course of chest X-ray interpretation for the diagnosis of paediatric TB

Melingui BF, Leroy-Terquem E, Palmer M, Taguebue JV, Wachinou AP,  et al.
2024-02-01 • IJTLD OPEN
2024-02-01 • IJTLD OPEN
BACKGROUND
Chest X-ray (CXR) interpretation is challenging for the diagnosis of paediatric TB. We assessed the performance of a three half-day CXR training module for healthcare work...

Acceptability of decentralizing childhood tuberculosis diagnosis in low-income countries with high tuberculosis incidence: Experiences and perceptions from health care workers in Sub-Saharan Africa and South-East Asia

Joshi B, De Lima YV, Massom DM, Kaing S, Banga MF,  et al.
2023-10-11 • PLOS Global Public Health
2023-10-11 • PLOS Global Public Health
Decentralizing childhood tuberculosis services, including diagnosis, is now recommended by the WHO and could contribute to increasing tuberculosis detection in high burden countries. How...

Mortality and cause of death in children with presumptive disseminated tuberculosis

Bonnet MMB, Nordholm AC, Ssekyanzi B, Byamukama O, Orikiriza P,  et al.
2023-03-23 • Pediatrics
2023-03-23 • Pediatrics
BACKGROUND AND OBJECTIVES:
Children experience high tuberculosis (TB)-related mortality but causes of death among those with presumptive TB are poorly documented. We describe the mor...

Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Marcy O, Wobudeya E, Font H, Vessière A, Chabala C,  et al.
2023-03-01 • Lancet Infectious Diseases
2023-03-01 • Lancet Infectious Diseases
BACKGROUND
Tuberculosis diagnosis might be delayed or missed in children with severe pneumonia because this diagnosis is usually only considered in cases of prolonged symptoms or ant...

Tackling mortality due to childhood tuberculosis

Godreuil S, Marcy O, Wobudeya E, Bonnet MMB, Solassol J
2018-03-23 • Lancet Public Health
2018-03-23 • Lancet Public Health

Tuberculosis diagnostic accuracy of stool Xpert MTB/RIF and urine AlereLAM in vulnerable children

Orikiriza P, Smith JS, Ssekyanzi B, Nyehangane D, Mugisha IT,  et al.
2021-06-17 • European Respiratory Journal
2021-06-17 • European Respiratory Journal
BACKGROUND
Non-sputum-based diagnostic approaches are crucial in children at high risk of disseminated tuberculosis (TB) who cannot expectorate sputum. We evaluated the diagnostic ac...

Knowledge, attitudes and practices on childhood TB among healthcare workers

Joshi B, Font H, Wobudeya E, Nanfuka M, Kobusingye A,  et al.
2022-03-01 • International Journal of Tuberculosis and Lung Disease
2022-03-01 • International Journal of Tuberculosis and Lung Disease
BACKGROUND
Increasing childhood TB case detection requires the deployment of diagnostic services at peripheral healthcare level. Capacity and readiness of healthcare workers (HCWs) a...

Towards early inclusion of children in tuberculosis drugs trials: a consensus statement

Nachman S, Ahmed AO, Amanullah F, Becerra M, Botgros R,  et al.
2015-06-01 • Lancet Infectious Diseases
2015-06-01 • Lancet Infectious Diseases
Children younger than 18 years account for a substantial proportion of patients with tuberculosis worldwide. Available treatments for paediatric drug-susceptible and drug-resistant tuber...