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Showing 1 - 9 of 9 Items
Showing 1 - 9 of 9 Items
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Journal Article
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Research

Population pharmacokinetics of lumefantrine in pregnant and nonpregnant women with uncomplicated Plasmodium falciparum malaria in Uganda

Kloprogge F, Piola P, Dhorda M, Muwanga S, Turyakira E,  et al.
2013-11-13 • CPT: Pharmacometrics and Systems Pharmacology
2013-11-13 • CPT: Pharmacometrics and Systems Pharmacology
Pregnancy alters the pharmacokinetic properties of many antimalarial compounds. The objective of this study was to evaluate the pharmacokinetic properties of lumefantrine in pregnant and...
Journal Article
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Research

Performance of a Histidine-Rich Protein 2 Rapid Diagnostic Test, Paracheck Pf(R), for Detection of Malaria Infections in Ugandan Pregnant Women

Dhorda M, Piola P, Nyehangane D, Tumwebaze B, Nalusaji A,  et al.
2012-01-01 • PLOS One
2012-01-01 • PLOS One
Abstract. Improved laboratory diagnosis is critical to reduce the burden of malaria in pregnancy. Peripheral blood smears appear less sensitive than Plasmodium falciparum histidine-rich ...
Journal Article
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Research

Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial

Muehlenbachs A, Nabasumba C, McGready R, Turyakira E, Tumwebaze B,  et al.
2012-05-03 • Malaria Journal
2012-05-03 • Malaria Journal
BACKGROUND
Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, rando...
Journal Article
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Research

Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria

Van Malderen C, Van Geertruyden JP, Machevo S, Gonzalez R, Bassat Q,  et al.
2012-04-30 • Malaria Journal
2012-04-30 • Malaria Journal
BACKGROUND
Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few ...
Journal Article
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Research

Heterogeneous decrease in malaria prevalence in children over a six-year period in south-western Uganda

De Beaudrap P, Nabasumba C, Grandesso F, Turyakira E, Schramm B,  et al.
2011-05-18 • Malaria Journal
2011-05-18 • Malaria Journal
BACKGROUND
Malaria is a major public health problem, especially for children. However, recent reports suggest a decline in the malaria burden. The aim of this study was to assess the...
Journal Article
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Research

Impact of malaria during pregnancy on pregnancy outcomes in a Ugandan prospective cohort with intensive malaria screening and prompt treatment

De Beaudrap P, Turyakira E, White LJ, Nabasumba C, Tumwebaze B,  et al.
2013-04-24 • Malaria Journal
2013-04-24 • Malaria Journal
BACKGROUND
Malaria in pregnancy (MiP) is a major public health problem in endemic areas of sub-Saharan Africa and has important consequences on birth outcome. Because MiP is a comple...
Journal Article
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Research

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children

Ashley EA, Pinoges LLP, Turyakira E, Dorsey G, Checchi F,  et al.
2008-08-09 • Malaria Journal
2008-08-09 • Malaria Journal
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with im...
Journal Article
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Research

Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial

Piola P, Nabasumba C, Turyakira E, Dhorda M, Lindegardh N,  et al.
2010-11-01 • Lancet Infectious Diseases
2010-11-01 • Lancet Infectious Diseases
BACKGROUND: Malaria in pregnancy is associated with maternal and fetal morbidity and mortality. In 2006, WHO recommended use of artemisinin-based combination treatments during the second...
Journal Article
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Research

Timing of malaria in pregnancy and impact on infant growth and morbidity: A cohort study in Uganda

De Beaudrap P, Turyakira E, Nabasumba C, Tumwebaze B, Piola P,  et al.
2016-02-16 • Malaria Journal
2016-02-16 • Malaria Journal
BACKGROUND
Malaria in pregnancy (MiP) is a major cause of fetal growth restriction and low birth weight in endemic areas of sub-Saharan Africa. Understanding of the impact of MiP on ...