logo
Science Portal
Copyright © Médecins Sans Frontières
v2.1.5655.produseast1
About MSF Science Portal
About
Contact Us
Frequently Asked Questions (FAQs)
Privacy Policy
Terms of Use
Copyright © Médecins Sans Frontières
v2.1.5655.produseast1
Showing 1 - 8 of 8 Items
Showing 1 - 8 of 8 Items
Sort By: Relevance
  • Newest to oldest
  • Oldest to newest
  • Relevance
Journal Article
|
Research

Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options

Singh A, Sunpath H, Green TN, Padayachi N, Hiramen K,  et al.
2011-11-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2011-11-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
BACKGROUND
Drug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isol...
Journal Article
|
Research

Expanding the use of dolutegravir-based antiretroviral therapy in multidrug-resistant TB

Murphy RA, 
Journal Article
|
Research
Journal Article
|
Research
Journal Article
|
Research

Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis: a case report from KwaZulu-Natal, South Africa

Journal Article
|
Research
Journal Article
|
Research
Journal Article
|
Research
Douglas-Jones B, 
Mucinya G, 
Sunpath H, 
Govender T
2021-09-01 • International Journal of Tuberculosis and Lung Disease
2021-09-01 • International Journal of Tuberculosis and Lung Disease
The wider availability of dolutegravir (DTG) containing HIV therapy for patients living with multidrug-resistant TB (MDR-TB) presents several advantages. DTG-based antiretroviral therapy...

Double-dose lopinavir-ritonavir in combination with rifampicin-based anti-tuberculosis treatment in South Africa

Sunpath H, Winternheimer P, Cohen S, Tennant I, Chelin N,  et al.
2014-06-01 • International Journal of Tuberculosis and Lung Disease
2014-06-01 • International Journal of Tuberculosis and Lung Disease
BACKGROUND
The optimal treatment for tuberculosis (TB) in human immunodeficiency virus (HIV) infected patients in resource-poor settings receiving lopinavir-ritonavir (LPV/r) based ...

Mutational correlates of virological failure in individuals receiving a WHO-recommended tenofovir-containing first-line regimen: Aa international collaboration

Rhee SY, Varghese B, Holmes SP, Van Zyl GU, Steegen K,  et al.
2017-03-19 • EBioMedicine
2017-03-19 • EBioMedicine
Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in 20% to 60% of individuals with virological failure (VF) on a WHO-recommended TDF-cont...
Murphy RA, 
France H, 
Sunpath H, 
Gordon ML, 
Marconi VC, 
et al.
2009-02-01 • Journal of Tropical Pediatrics
2009-02-01 • Journal of Tropical Pediatrics
The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antire...

Coadministration of lopinavir/ritonavir and rifampicin in HIV and tuberculosis co-infected adults in South Africa

Murphy RA, Marconi VC, Gandhi R, Kuritzkes DR, Sunpath H
2012-09-28 • PLOS One
2012-09-28 • PLOS One
In HIV-infected patients receiving rifampicin-based treatment for tuberculosis (TB), the dosage of lopinavir/ritonavir (LPV/r) is adjusted to prevent sub-therapeutic lopinavir concentrat...

Low uptake of antiretroviral therapy after admission with human immunodeficiency virus and tuberculosis in KwaZulu-Natal, South Africa

Murphy RA, Sunpath H, Taha B, Kappagoda S, Maphasa KT,  et al.
2010-07-01 • International Journal of Tuberculosis and Lung Disease
2010-07-01 • International Journal of Tuberculosis and Lung Disease
OBJECTIVES
A prospective cohort study was conducted among human immunodeficiency virus (HIV) infected in-patients with tuberculosis (TB) or other opportunistic infections (OIs) in So...

Early warning indicators for first-line virologic failure independent of adherence measures in a South African urban clinic

Marconi VC, Wu B, Hampton J, Ordonez CE, Johnson BA,  et al.
2013-12-09 • AIDS Patient Care and STDs
2013-12-09 • AIDS Patient Care and STDs
Abstract We sought to develop individual-level Early Warning Indicators (EWI) of virologic failure (VF) for clinicians to use during routine care complementing WHO population-level EWI. ...