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Showing 1 - 20 of 37 Items
Showing 1 - 20 of 37 Items
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Journal Article
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Protocol

Mismatch of supply and demand: Marburg virus disease outbreaks need countermeasures but will not provide opportunity for clinical trials

Sprecher A, Van Herp M
2024-11-26 • Marburg Virus: Methods and Protocols
2024-11-26 • Marburg Virus: Methods and Protocols

In many ways, Marburg virus disease resembles the more well-known Ebola virus disease: The clinical syndrom...

Journal Article
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Short Report

Evaluation of centralised and decentralised models of care during the 2020 Ebola Virus Disease outbreak in Equateur Province, Democratic Republic of the Congo: A brief report

Lampaert E, Nsio JM, Nair D, Mashako M, De Weggheleire A,  et al.
2024-08-28 • F1000Research
2024-08-28 • F1000Research

BACKGROUND

Tradi...

Journal Article
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Research

Methodological issues of retrospective surveys for measuring mortality of highly clustered diseases: case study of the 2014–16 Ebola outbreak in Bo District, Sierra Leone

Caleo G, Lokuge K, Kardamanidis K, Greig J, Belava J,  et al.
2024-04-25 • Global Health Action
2024-04-25 • Global Health Action
BACKGROUND
There is a lack of empirical data on design effects (DEFF) for mortality rate for highly clustered data such as with Ebola virus disease (EVD), along with a lack of docume...
Journal Article
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Commentary

An oral antiviral for Ebola disease

Sprecher A, Van Herp M
2024-03-15 • Science
2024-03-15 • Science
For those exposed to filovirus, such as Sudan virus and Ebola virus, a new study offers hope.
Journal Article
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Commentary

Perspectives on advancing countermeasures for Filovirus disease: Report from a multi-sector meeting

Sprecher A, Cross RW, Marzi A, Martins KA, Wolfe D,  et al.
2023-08-19 • Journal of Infectious Diseases
2023-08-19 • Journal of Infectious Diseases
Although there are now approved treatments and vaccines for Ebola virus disease (EVD), the case fatality of EVD remains unacceptably high even when treated with the newly approved therap...
Journal Article
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Commentary

Understanding the key to outbreak control — Sudan Virus Disease in Uganda

Sprecher A
2022-11-16 • New England Journal of Medicine
2022-11-16 • New England Journal of Medicine
Journal Article
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Letter

Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa

Carroll MW, Matthews DA, Hiscox JA, Elmore MJ, Pollakis G,  et al.
2015-06-17 • Nature
2015-06-17 • Nature
West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded. Until now, there have been 27,013 reported cases and 11,134 deaths. The origin of the ...
Journal Article
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Research

Plasmodium parasitemia associated with increased survival in Ebola virus-infected patients

Rosenke K, Adjemian J, Munster VJ, Marzi A, Falzarano D,  et al.
2016-08-15 • Clinical Infectious Diseases
2016-08-15 • Clinical Infectious Diseases
BACKGROUND
The ongoing Ebola outbreak in West Africa has resulted in 28 646 suspected, probable, and confirmed Ebola virus infections. Nevertheless, malaria remains a large public he...
Journal Article
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Research

Clinical chemistry of patients with Ebola in Monrovia, Liberia

de Wit E, Kramer S, Prescott JB, Rosenke K, Falzarano D,  et al.
2016-07-28 • Journal of Infectious Diseases
2016-07-28 • Journal of Infectious Diseases
The development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eterna...
Journal Article
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Research

Ebola outbreak in rural West Africa: epidemiology, clinical features and outcomes

Dallatomasinas S, Crestani R, Squire JS, Declerck H, Caleo GNC,  et al.
2015-01-07 • Tropical Medicine and International Health
2015-01-07 • Tropical Medicine and International Health
To describe Ebola cases in the district Ebola Management Centre of in Kailahun, a remote rural district of Sierra Leone, in terms of geographic origin, patient and hospitalization charac...
Journal Article
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Research

Environmental contamination and persistence of Ebola virus RNA in an Ebola treatment center

Poliquin PG, Vogt F, Kasztura M, Leung A, Deschambault Y,  et al.
2016-06-30 • Journal of Infectious Diseases
2016-06-30 • Journal of Infectious Diseases
BACKGROUND
Ebola viruses (EBOVs) are primarily transmitted by contact with infected body fluids. Ebola treatment centers (ETCs) contain areas that are exposed to body fluids through ...
Journal Article
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Commentary

New filovirus disease classification and nomenclature

De Clerck H, Nanclares C, Sprecher A, Van Herp M, Wolz A
2019-03-29 • Nature Microbiology
2019-03-29 • Nature Microbiology
The recent large outbreak of Ebola virus disease (EVD) in Western Africa resulted in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved our und...
Journal Article
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Commentary

Handle Survivors with Care

Sprecher A
2015-10-14 • New England Journal of Medicine
2015-10-14 • New England Journal of Medicine
Journal Article
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Commentary

Overlooking the Importance of Immunoassays - Authors' Reply

Cnops L, van Griensven J, Honko AN, Bausch DG, Sprecher A,  et al.
2016-09-19 • Lancet Infectious Diseases
2016-09-19 • Lancet Infectious Diseases
Journal Article
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Review

Essentials of Filoviral Load Quantification

Cnops L, van Griensven J, Honko AN, Bausch DG, Sprecher A,  et al.
2016-06-10 • Lancet Infectious Diseases
2016-06-10 • Lancet Infectious Diseases
Quantitative measurement of viral load is an important parameter in the management of filovirus disease outbreaks because viral load correlates with severity of disease, survival, and in...
Journal Article
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Review

Clinical Management of Ebola Virus Disease Patients in Low-Resource Settings

Sprecher A, Van Herp M, Rollin PE
2017-06-24 • Current Topics in Microbiology and Immunology
2017-06-24 • Current Topics in Microbiology and Immunology
Journal Article
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Research

The use of a mobile laboratory unit in support of patient management and epidemiological surveillance during the 2005 Marburg outbreak in Angola

Grolla A, Jones SM, Fernando L, Strong JE, Stroher U,  et al.
2011-05-24 • PLOS Neglected Tropical Diseases
2011-05-24 • PLOS Neglected Tropical Diseases
Background: Marburg virus (MARV), a zoonotic pathogen causing severe hemorrhagic fever in man, has emerged in Angola resulting in the largest outbreak of Marburg hemorrhagic fever (MHF) ...
Journal Article
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Commentary

More Challenges From Ebola: Infection of the Central Nervous System

Wong G, Qiu X, Bi Y, Formenty P, Sprecher A,  et al.
2016-10-15 • Journal of Infectious Diseases
2016-10-15 • Journal of Infectious Diseases
Cases of relapsed Ebola virus disease involving symptoms in the central nervous system are reminiscent of our past observations with some nonhuman primates (NHPs) that survived acute Ebo...
Journal Article
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Commentary

Ebola virus is unlikely to become endemic in West Africa

Sprecher A, Feldman H, Hensley L, Kobinger GP, Nichol ST,  et al.
2016-02-24 • Nature Microbiology
2016-02-24 • Nature Microbiology
Concern over Ebola becoming endemic in West Africa has appeared in the medical and lay media. Routes of transmission, rates of viral evolution, suitability of humans as hosts and rarity ...
Journal Article
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Research

Feasibility of Xpert Ebola Assay in Médecins Sans Frontières Ebola Program, Guinea

Van der Bergh R, Chaillet P, Sow MS, Amand M, van Vyve C,  et al.
2016-02-01 • Emerging Infectious Diseases
2016-02-01 • Emerging Infectious Diseases
Rapid diagnostic methods are essential in control of Ebola outbreaks and lead to timely isolation of cases and improved epidemiologic surveillance. Diagnosis during Ebola outbreaks in We...