Conference Material > Poster
Teklehaimanot BF, Filina Y, Keating P, Morales AM, Sahelie B, et al.
MSF Paediatric Days 2024. 3 May 2024; DOI:10.57740/QJQJ8Q
Journal Article > ResearchFull Text
Confl Health. 30 January 2024; Volume 18 (Issue 1); 13.; DOI:10.1186/s13031-024-00571-y
Baertlein L, Dubad BA, Sahelie B, Damulak IC, Osman M, et al.
Confl Health. 30 January 2024; Volume 18 (Issue 1); 13.; DOI:10.1186/s13031-024-00571-y
BACKGROUND
This study evaluated an early warning, alert and response system for a crisis-affected population in Doolo zone, Somali Region, Ethiopia, in 2019–2021, with a history of epidemics of outbreak-prone diseases. To adequately cover an area populated by a semi-nomadic pastoralist, or livestock herding, population with sparse access to healthcare facilities, the surveillance system included four components: health facility indicator-based surveillance, community indicator- and event-based surveillance, and alerts from other actors in the area. This evaluation described the usefulness, acceptability, completeness, timeliness, positive predictive value, and representativeness of these components.
METHODS
We carried out a mixed-methods study retrospectively analysing data from the surveillance system February 2019–January 2021 along with key informant interviews with system implementers, and focus group discussions with local communities. Transcripts were analyzed using a mixed deductive and inductive approach. Surveillance quality indicators assessed included completeness, timeliness, and positive predictive value, among others.
RESULTS
1010 signals were analysed; these resulted in 168 verified events, 58 alerts, and 29 responses. Most of the alerts (46/58) and responses (22/29) were initiated through the community event-based branch of the surveillance system. In comparison, one alert and one response was initiated via the community indicator-based branch. Positive predictive value of signals received was about 6%. About 80% of signals were verified within 24 h of reports, and 40% were risk assessed within 48 h. System responses included new mobile clinic sites, measles vaccination catch-ups, and water and sanitation-related interventions. Focus group discussions emphasized that responses generated were an expected return by participant communities for their role in data collection and reporting. Participant communities found the system acceptable when it led to the responses they expected. Some event types, such as those around animal health, led to the community’s response expectations not being met.
CONCLUSIONS
Event-based surveillance can produce useful data for localized public health action for pastoralist populations. Improvements could include greater community involvement in the system design and potentially incorporating One Health approaches.
This study evaluated an early warning, alert and response system for a crisis-affected population in Doolo zone, Somali Region, Ethiopia, in 2019–2021, with a history of epidemics of outbreak-prone diseases. To adequately cover an area populated by a semi-nomadic pastoralist, or livestock herding, population with sparse access to healthcare facilities, the surveillance system included four components: health facility indicator-based surveillance, community indicator- and event-based surveillance, and alerts from other actors in the area. This evaluation described the usefulness, acceptability, completeness, timeliness, positive predictive value, and representativeness of these components.
METHODS
We carried out a mixed-methods study retrospectively analysing data from the surveillance system February 2019–January 2021 along with key informant interviews with system implementers, and focus group discussions with local communities. Transcripts were analyzed using a mixed deductive and inductive approach. Surveillance quality indicators assessed included completeness, timeliness, and positive predictive value, among others.
RESULTS
1010 signals were analysed; these resulted in 168 verified events, 58 alerts, and 29 responses. Most of the alerts (46/58) and responses (22/29) were initiated through the community event-based branch of the surveillance system. In comparison, one alert and one response was initiated via the community indicator-based branch. Positive predictive value of signals received was about 6%. About 80% of signals were verified within 24 h of reports, and 40% were risk assessed within 48 h. System responses included new mobile clinic sites, measles vaccination catch-ups, and water and sanitation-related interventions. Focus group discussions emphasized that responses generated were an expected return by participant communities for their role in data collection and reporting. Participant communities found the system acceptable when it led to the responses they expected. Some event types, such as those around animal health, led to the community’s response expectations not being met.
CONCLUSIONS
Event-based surveillance can produce useful data for localized public health action for pastoralist populations. Improvements could include greater community involvement in the system design and potentially incorporating One Health approaches.
Conference Material > Slide Presentation
Ali Dubad B, Baertlein L, Piening T, Chindong I, Sahelie B, et al.
MSF Scientific Days International 2022. 12 May 2022; DOI:10.57740/8bp2-4234
Conference Material > Poster
Steegemans IM, Sisay K, Nshimiyimana E, Gebrewold G, Piening T, et al.
MSF Scientific Days International 2021: Research. 18 May 2021
Conference Material > Abstract
Ali Dubad B, Baertlein L, Piening T, Chindong I, Sahelie B, et al.
MSF Scientific Days International 2022. 12 May 2022; DOI:10.57740/s9dr-mf76
INTRODUCTION
The Somali Region is one of the least developed regions of Ethiopia, with low coverage of healthcare services and recurrent disease outbreaks, floods, and malnutrition emergencies. MSF has been providing medical assistance in the Doolo Zone, Somali Region, since 2007. Following multiple disease outbreaks in 2017, MSF shifted focus to work primarily on early outbreak detection and provision of a timely response. In 2019, MSF established a “Tea Team surveillance team”; this combines health facility data with that from community indicator- and event-based surveillance systems. Data are collected from 32 locations (17 surveillance only and 15 non-permanent mobile clinic sites), as well as alerts from other actors in Doolo Zone. We aimed to evaluate the usefulness of the data generated by these different components.
METHODS
We used a mixed methods approach. Description of the surveillance system, quantitative analysis of retrospective data between February 2019 and January 2021, and focus group discussions were the main methods used to evaluate usefulness, acceptability, and other surveillance attributes. Quantitative analyses were done using R software (R Core Team, 2014) while qualitative data analysis was performed with NVivo software (QSR International Pty Ltd, Australia).
ETHICS
Permission to conduct the study was obtained from the Somali Regional Health Bureau. This study was approved by the MSF Ethics Review Board.
RESULTS
Over 1200 signals were reported to the Tea Team surveillance system over the evaluation period, with the majority being reported via the community event-based surveillance (CEBS) component. There were a total of 31 responses conducted between February 2019 and January 2021. 22 (84.6%) originated from CEBS system signals, one (3.8%) was from the community indicator-based surveillance (CIBS) system, 2 (7.7%) were from health facility indicator-based surveillance (HFIBS), and 6 (23.1%) came from other event-based surveillance systems. Most responses were triggered by population movements, suspected measles, and suspected acute watery diarrhoea. No responses arose from acute jaundice syndrome signals. MSF staff found the “Tea Team surveillance system” to have higher acceptability in non-emergency situations, but indicated lower acceptability during a crisis, due to data processing times and rigidity of the HFIBS online database. The surveillance system has complex data management procedures leading to potential underreporting of signals and difficulties with routine data quality monitoring. Project staff considered the CEBS and CIBS components to be more flexible than HFIBS. The system was sufficiently flexible to integrate with Covid-19 surveillance.
CONCLUSION
The Tea Team surveillance system is a comprehensive and useful system to detect and respond to public health events in a pastoralist population. Simplification of the surveillance system and greater standardisation of the data management processes will increase the utility of the system.
CONFLICTS OF INTEREST
None declared
The Somali Region is one of the least developed regions of Ethiopia, with low coverage of healthcare services and recurrent disease outbreaks, floods, and malnutrition emergencies. MSF has been providing medical assistance in the Doolo Zone, Somali Region, since 2007. Following multiple disease outbreaks in 2017, MSF shifted focus to work primarily on early outbreak detection and provision of a timely response. In 2019, MSF established a “Tea Team surveillance team”; this combines health facility data with that from community indicator- and event-based surveillance systems. Data are collected from 32 locations (17 surveillance only and 15 non-permanent mobile clinic sites), as well as alerts from other actors in Doolo Zone. We aimed to evaluate the usefulness of the data generated by these different components.
METHODS
We used a mixed methods approach. Description of the surveillance system, quantitative analysis of retrospective data between February 2019 and January 2021, and focus group discussions were the main methods used to evaluate usefulness, acceptability, and other surveillance attributes. Quantitative analyses were done using R software (R Core Team, 2014) while qualitative data analysis was performed with NVivo software (QSR International Pty Ltd, Australia).
ETHICS
Permission to conduct the study was obtained from the Somali Regional Health Bureau. This study was approved by the MSF Ethics Review Board.
RESULTS
Over 1200 signals were reported to the Tea Team surveillance system over the evaluation period, with the majority being reported via the community event-based surveillance (CEBS) component. There were a total of 31 responses conducted between February 2019 and January 2021. 22 (84.6%) originated from CEBS system signals, one (3.8%) was from the community indicator-based surveillance (CIBS) system, 2 (7.7%) were from health facility indicator-based surveillance (HFIBS), and 6 (23.1%) came from other event-based surveillance systems. Most responses were triggered by population movements, suspected measles, and suspected acute watery diarrhoea. No responses arose from acute jaundice syndrome signals. MSF staff found the “Tea Team surveillance system” to have higher acceptability in non-emergency situations, but indicated lower acceptability during a crisis, due to data processing times and rigidity of the HFIBS online database. The surveillance system has complex data management procedures leading to potential underreporting of signals and difficulties with routine data quality monitoring. Project staff considered the CEBS and CIBS components to be more flexible than HFIBS. The system was sufficiently flexible to integrate with Covid-19 surveillance.
CONCLUSION
The Tea Team surveillance system is a comprehensive and useful system to detect and respond to public health events in a pastoralist population. Simplification of the surveillance system and greater standardisation of the data management processes will increase the utility of the system.
CONFLICTS OF INTEREST
None declared
Conference Material > Poster
Sahelie B, Ali Dubad B, Piening T, Chindong I, Osman M, et al.
MSF Scientific Days International 2022. 9 May 2022; DOI:10.57740/63dm-5748
Journal Article > ResearchFull Text
PLoS Negl Trop Dis. 9 February 2022; Volume 16 (Issue 2); e0010148.; DOI:10.1371/journal.pntd.0010148
Steegemans IM, Sisay K, Nshimiyimana E, Gebrewold G, Piening T, et al.
PLoS Negl Trop Dis. 9 February 2022; Volume 16 (Issue 2); e0010148.; DOI:10.1371/journal.pntd.0010148
BACKGROUND
Millions of people are bitten by venomous snakes annually, causing high mortality and disability, but the true burden of this neglected health issue remains unknown. Since 2015, Médecins Sans Frontières has been treating snakebite patients in a field hospital in north-west Ethiopia. Due to the poor market situation for effective and safe antivenoms for Sub-Saharan Africa, preferred antivenom was not always available, forcing changes in choice of antivenom used. This study describes treatment outcomes and the effectiveness and safety of different antivenoms used.
METHODOLOGY/PRINCIPAL FINDINGS:
This retrospective observational study included 781 snakebite patients presenting at the field hospital between 2015 and 2019. Adjusted odds ratios, 95%-CI and p-values were used to compare the treatment outcome of patients treated with Fav-Afrique (n = 149), VacSera (n = 164), and EchiTAb-PLUS-ICP (n = 156) antivenom, and to identify the risk of adverse reactions for each antivenom. Whereas only incidental snakebite cases presented before 2015, after treatment was made available, cases rapidly increased to 1,431 in 2019. Envenomation was mainly attributed to North East African saw-scaled viper (Echis pyramidum) and puff adder (Bitis arietans). Patients treated with VacSera antivenom showed lower chance of uncomplicated treatment outcome (74.4%) compared to Fav-Afrique (93.2%) and EchiTAb-PLUS-ICP (90.4%). VacSera and EchiTAb-PLUS-ICP were associated with 16- and 6-fold adjusted odds of treatment reaction compared to Fav-Afrique, respectively, and VacSera was weakly associated with higher odds of death.
CONCLUSIONS/SIGNIFICANCE
Snakebite frequency is grossly underreported unless treatment options are available. Although EchiTAb-PLUS-ICP showed favorable outcomes in this retrospective analysis, prospective randomized trials are needed to evaluate the effectiveness and safety of the most promising antivenoms for Sub-Saharan Africa. Structural investment in sustained production and supply of antivenom is urgently needed.
Millions of people are bitten by venomous snakes annually, causing high mortality and disability, but the true burden of this neglected health issue remains unknown. Since 2015, Médecins Sans Frontières has been treating snakebite patients in a field hospital in north-west Ethiopia. Due to the poor market situation for effective and safe antivenoms for Sub-Saharan Africa, preferred antivenom was not always available, forcing changes in choice of antivenom used. This study describes treatment outcomes and the effectiveness and safety of different antivenoms used.
METHODOLOGY/PRINCIPAL FINDINGS:
This retrospective observational study included 781 snakebite patients presenting at the field hospital between 2015 and 2019. Adjusted odds ratios, 95%-CI and p-values were used to compare the treatment outcome of patients treated with Fav-Afrique (n = 149), VacSera (n = 164), and EchiTAb-PLUS-ICP (n = 156) antivenom, and to identify the risk of adverse reactions for each antivenom. Whereas only incidental snakebite cases presented before 2015, after treatment was made available, cases rapidly increased to 1,431 in 2019. Envenomation was mainly attributed to North East African saw-scaled viper (Echis pyramidum) and puff adder (Bitis arietans). Patients treated with VacSera antivenom showed lower chance of uncomplicated treatment outcome (74.4%) compared to Fav-Afrique (93.2%) and EchiTAb-PLUS-ICP (90.4%). VacSera and EchiTAb-PLUS-ICP were associated with 16- and 6-fold adjusted odds of treatment reaction compared to Fav-Afrique, respectively, and VacSera was weakly associated with higher odds of death.
CONCLUSIONS/SIGNIFICANCE
Snakebite frequency is grossly underreported unless treatment options are available. Although EchiTAb-PLUS-ICP showed favorable outcomes in this retrospective analysis, prospective randomized trials are needed to evaluate the effectiveness and safety of the most promising antivenoms for Sub-Saharan Africa. Structural investment in sustained production and supply of antivenom is urgently needed.