Search Results | MSF Science Portal

Journal Article

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Research

Nathan N, Borel T, Djibo A, Evans D, Djibo S, et al.

2008-04-14 • Lancet

BACKGROUND: In sub-Saharan Africa in the 1990s, more than 600,000 people had epidemic meningococcal meningitis, of whom 10% died. The current recommended treatment by WHO is short-course...

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Research

Minetti A, Camelique O, Hsa Thaw K, Thi SS, Swaddiwudhipong W, et al.

2010-12-01 • International Journal of Tuberculosis and Lung Disease

SETTING
Although tuberculosis (TB) is a curable disease, it remains a major global health problem and an important cause of morbidity and mortality among vulnerable populations, incl...

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Research

Rolland E, Checchi F, Pinoges LLP, Balkan S, Guthmann JP, et al.

2006-04-01 • Tropical Medicine and International Health

OBJECTIVE: To compare the cost-effectiveness of malaria treatment based on presumptive diagnosis with that of malaria treatment based on rapid diagnostic tests (RDTs). METHODS: We calcul...

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Research

Schramm B, Valeh P, Baudin E, Mazinda CS, Smith R, et al.

2013-07-17 • Malaria Journal

BACKGROUND
Safety surveillance of widely used artemisinin-based combination therapy (ACT) is essential, but tolerability data in the over five years age group are largely anecdotal.<...

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Research

Bastard M, Pinoges LLP, Balkan S, Szumilin E, Ferreyra C, et al.

2012-11-07 • PLOS One

Ensuring long-term adherence to therapy is essential for the success of HIV treatment. As access to viral load monitoring and genotyping is poor in resource-limited settings, a simple to...

Journal Article

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Research

Schramm B, Valeh P, Baudin E, Mazinda CS, Smith R, et al.

2013-07-17 • Malaria Journal

BACKGROUND
Prospective efficacy monitoring of anti-malarial treatments is imperative for timely detection of resistance development. The in vivo efficacy of artesunate-amodiaquine (A...

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Research

Dubray C, Ibrahim SA, Abdelmutalib M, Guerin PJ, Dantoine F, et al.

2008-03-01 • Annals of Tropical Paediatrics

BACKGROUND: Systemic antibiotics are routinely prescribed for severe acute malnutrition (SAM). However, there is no consensus regarding the most suitable regimen. In a therapeutic feedin...

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Research

Olliaro PL, Pinoges LLP, Checchi F, Vaillant M, Guthmann JP

2008-01-01 • Tropical Medicine and International Health

OBJECTIVE: Parasites may recur asymptomatically after initial clearance by antimalarial treatment. Current guidelines recommend treatment only when patients develop symptoms or at the en...

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Research

Pujades-Rodriguez M, Dantony E, Pinoges LLP, Ecochard R, Etard JF, et al.

2011-11-21 • PLOS One

BACKGROUND
To compare the incidence and timing of toxicity associated with the use of a reduced dose of stavudine from 40 to 30 mg in first-line antiretroviral therapy (ART) for HIV ...

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Research

Guerin PJ, Naess LM, Fogg C, Rosenqvist E, Pinoges LLP, et al.

2008-12-02 • PLOS Neglected Tropical Diseases

BACKGROUND: Neisseria meningitidis serogroup A is the main causative pathogen of meningitis epidemics in sub-Saharan Africa. In recent years, serogroup W135 has also been the cause of ep...

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Research

Guthmann JP, Pinoges LLP, Checchi F, Cousens S, Balkan S, et al.

2006-11-01 • Antimicrobial Agents and Chemotherapy

The objectives of these analyses were to assess the feasibility of the latest WHO recommendations (28-day follow-up with PCR genotyping) for the assessment of antimalarial drug efficacy ...

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Research

Calmy A, Pinoges LLP, Szumilin E, Zachariah R, Ford NP, et al.

2006-05-12 • AIDS

BACKGROUND
The use fixed-dose combination (FDC) is a critical tool in improving HAART. Studies on the effectiveness of combined lamivudine, stavudine and nevirapine (3TC/d4T/NVP) are...

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Research

Ashley EA, Pinoges LLP, Turyakira E, Dorsey G, Checchi F, et al.

2008-08-09 • Malaria Journal

BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with im...

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Research

Priotto G, Kabakyenga JK, Pinoges LLP, Ruiz A, Eriksson T, et al.

2008-01-25 • Transactions of the Royal Society of Tropical Medicine and Hygiene

Drug-resistant malaria is spreading in Africa. The few available drugs might be safeguarded if combined with an artemisinin derivative. We investigated the efficacy, safety, and tolerabi...

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Research

Priotto G, Pinoges LLP, Fursa IB, Burke B, Nicolay N, et al.

2008-03-05 • British Medical Journal (BMJ)

Objective: To assess the safety and effectiveness of eflornithine as first line treatment for human African trypanosomiasis. Design: Cohort study. Setting: Control programme in Ibba, sou...

Journal Article

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Research

Lee SJ, Stepniewska K, Anstey NM, Ashley EA, Barnes KI, et al.

2008-08-01 • Malaria Journal

BACKGROUND: Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For compari...

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Research

Bonnet MMB, Pinoges LLP, Varaine FFV, Oberhauser BBO, O'Brien DP, et al.

2006-06-12 • AIDS

BACKGROUND: HAART reduces tuberculosis (TB) incidence in people living with HIV/AIDS but those starting HAART may develop active TB or subclinical TB may become apparent in the immune re...

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Research

Madec Y, Laureillard D, Pinoges LLP, Fernandez MAL, Prak N, et al.

2007-01-30 • AIDS

BACKGROUND: HAART efficacy was evaluated in a real-life setting in Phnom Penh (Médecins Sans Frontières programme) among severely immuno-compromised patients. METHODS: Factors associated...

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Research

Ahoua L, Ayikoru H, Gnauck K, Odaru G, Odar E, et al.

2010-02-01 • Journal of Tropical Pediatrics

Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining p...

Journal Article

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Research

Ferradini LLF, Laureillard D, Prak N, Ngeth C, Fernandez MAL, et al.

2007-11-12 • AIDS

OBJECTIVES: African and Asian cohort studies have demonstrated the feasibility and efficacy of HAART in resource-poor settings. The long-term virological outcome and clinico-immunologica...

Science Portal

Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study

Tuberculosis treatment in a refugee and migrant population: 20 years of experience on the Thai-Burmese border

Operational response to malaria epidemics: are rapid diagnostic tests cost-effective?

Tolerability and safety of artesunate-amodiaquine and artemether-lumefantrine fixed dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria: two open-label, randomized trials in Nimba County, Liberia

Timeliness of Clinic Attendance is a good predictor of Virological Response and Resistance to Antiretroviral drugs in HIV-infected patients

Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial

Treatment of severe malnutrition with 2-day intramuscular ceftriaxone vs 5-day amoxicillin

Risk associated with asymptomatic parasitaemia occurring post-antimalarial treatment

Toxicity associated with stavudine dose reduction from 40 to 30 mg in first-line antiretroviral therapy

Immunogenicity of fractional doses of tetravalent A/C/Y/W135 meningococcal polysaccharide vaccine: Results from a randomized non-inferiority controlled trial in Uganda

Methodological issues in the assessment of antimalarial drug treatment: Analysis of 13 studies in eight African countries from 2001 to 2004

Generic fixed-dose combination antiretroviral treatment in resource-poor settings: multicentric observational cohort

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children

Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda: a randomized, double-blind, placebo-controlled trial

Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study

The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria

Tuberculosis After HAART Initiation in HIV-Positive Patients from Five Countries with a High Tuberculosis Burden

Response to highly active antiretroviral therapy among severely immuno-compromised HIV-infected patients in Cambodia

Evaluation of a 5-year programme to prevent mother-to-child transmission of HIV infection in Northern Uganda

Positive Outcomes of HAART at 24 Months in HIV-Infected Patients in Cambodia