Journal Article > ResearchFull Text
Trans R Soc Trop Med Hyg. 1 February 2006; Volume 100 (Issue 2); DOI:10.1016/j.trstmh.2005.06.016
Campbell P, Baruah S, Narain K, Rogers C
Trans R Soc Trop Med Hyg. 1 February 2006; Volume 100 (Issue 2); DOI:10.1016/j.trstmh.2005.06.016
A four-arm drug sensitivity study compared chloroquine, sulfadoxine-pyrimethamine (SP), mefloquine and mefloquine-artesunate in Sonitpur and Karbi Anglong districts in Assam state, India. Two criteria were used to ascertain outcome: success of clinical treatment and parasitologic cure. In Sonitpur, at 14 days, there were 36/56 early and late treatment failures plus late parasitologic failures to chloroquine and 16/56 for SP. In Karbi Anglong, combined treatment failure at 14 days was 16/56 to chloroquine and 8/60 to SP. Mefloquine and mefloquine-artesunate demonstrated 93.9% and 93.6% sustained responses respectively at 42 days. High failure rates to both chloroquine and SP preclude the use of these drugs as first-line treatment for uncomplicated falciparum malaria in this region. A mefloquine-artesunate combination presents an effective alternative utilizing the currently recommended higher dose of mefloquine.
Journal Article > ResearchFull Text
Glob Health Action. 23 September 2016
Das M, Doleckova K, Shenoy R, Mahanta J, Narain K, et al.
Glob Health Action. 23 September 2016
One of the infections that mimic tuberculosis (TB) is paragonimiasis (PRG), a foodborne parasitic disease caused by lung flukes of the genus Paragonimus. In the northeastern states of India, TB and PRG are endemic; however, PRG is rarely included in the differential diagnosis of TB.