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Showing 1 - 14 of 14 Items
Showing 1 - 14 of 14 Items
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Research

Clinical utility of the FilmArray® meningitis/encephalitis panel in children with suspected central nervous system infection in a low-resource setting – a prospective study in southwestern Uganda

Rasti R, Kumbakumba E, Nanjebe D, Mlotshwa P, Nassejje M,  et al.
2025-03-22 • BMC Infectious Diseases
2025-03-22 • BMC Infectious Diseases

BACKGROUND

In low-resource settings, limited laboratory capacity adds to the burden of central nervous system (CNS) infections in children and spurs overuse of ...

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Impact of postpartum maternal fever or hypothermia on newborn and early infant illness and death in Southwestern Uganda

Mwanga-Amumpaire J, Adong J, Arinaitwe R, Nanjebe D, Orikiriza P,  et al.
2024-08-27 • BMC Pregnancy and Childbirth
2024-08-27 • BMC Pregnancy and Childbirth

BACKGROUND

Deaths ...

Practices and challenges related to antibiotic use in paediatric treatment in hospitals and health centres in Niger and Uganda: a mixed methods study

Mambula G, Nanjebe D, Munene A, Guindo O, Salifou A,  et al.
2023-07-11 • Antimicrobial Resistance and Infection Control
2023-07-11 • Antimicrobial Resistance and Infection Control
BACKGROUND
Antibiotic resistance is a significant public health problem and is responsible for high mortality in children and new-borns. Strengthening the rational use of antibiotics...

Immunogenicity and safety of fractional doses of 17D-213 yellow fever vaccine in children (YEFE): a randomised, double-blind, non-inferiority substudy of a phase 4 trial

Juan-Giner A, Namulwana ML, Kimathi D, Grantz KH, Fall G,  et al.
2023-04-28 • Lancet Infectious Diseases
2023-04-28 • Lancet Infectious Diseases
BACKGROUND
Current supply shortages constrain yellow fever vaccination activities, particularly outbreak response. Although fractional doses of all WHO-prequalified yellow fever vacc...

Assessment of the proportion of households with burn victims, associated risk factors and knowledge of burn injury prevention strategies in South Western Uganda. A population based cross sectional survey

Martin T, Nanjebe D, Atwine D
2023-03-01 • Burns
2023-03-01 • Burns
BACKGROUND
Burn injuries are a major cause of morbidity and mortality within Low- and Middle-income countries (LMICs). Most of these burn injuries occur at home with children most a...

Carriage prevalence and serotype distribution of Streptococcus pneumoniae prior to 10-valent pneumococcal vaccine introduction: a population-based cross-sectional study in South Western Uganda, 2014

Nackers F, Cohuet S, le Polain de Waroux O, Langendorf C, Nyehangane D,  et al.
2017-09-18 • Vaccine
2017-09-18 • Vaccine
BACKGROUND
Information on Streptococcus pneumoniae nasopharyngeal (NP) carriage before the pneumococcal conjugate vaccine (PCV) introduction is essential to monitor impact. The 10-va...

Capacity building in sub-Saharan Africa as part of the INTENSE-TBM project during the COVID-19 pandemic

Ariza-Vioque E, Ello F, Andriamamonjisoa H, Machault V, González-Martín J,  et al.
2022-06-29 • Infectious Diseases and Therapy
2022-06-29 • Infectious Diseases and Therapy
Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), with at least 100,000 cases per year and a mortality rate of up to 50% in individuals co-infected...

Antimicrobial-resistant infections among postpartum women at a Ugandan referral hospital

Bebell LM, Ngonzi J, Bazira J, Fajardo Y, Boatin AA,  et al.
2017-04-13 • PLOS One
2017-04-13 • PLOS One
INTRODUCTION
Puerperal sepsis causes 10% of maternal deaths in Africa, but prospective studies on incidence, microbiology and antimicrobial resistance are lacking.

METHODS

Antimicrobial treatment practices among Ugandan children with suspicion of central nervous system infection

Kemigisha E, Nanjebe D, Langendorf C, Aberrane S, Nyehangane D,  et al.
2018-10-09 • PLOS One
2018-10-09 • PLOS One
Acute central nervous system (CNS) infections in children in sub-Saharan Africa are often fatal. Potential contributors include late presentation, limited diagnostic capacity and inadequ...

Point-of-care approaches for meningitis diagnosis in a low-resource setting (Southwestern Uganda): observational cohort study protocol of the “PI-POC” trial

Gaudenzi G, Kumbakumba E, Rasti R, Nanjebe D, Reu P,  et al.
2020-11-04 • JMIR Research Protocols
2020-11-04 • JMIR Research Protocols
BACKGROUND
A timely differential diagnostic is essential to identify the etiology of central nervous system (CNS) infections in children, in order to facilitate targeted treatment, m...

Effect of high-dose rifampicin on efavirenz pharmacokinetics: drug-drug interaction randomized trial

Atwine D, Baudin E, Gele T, Muyindike WR, Mworozi K,  et al.
2020-01-30 • Journal of Antimicrobial Chemotherapy
2020-01-30 • Journal of Antimicrobial Chemotherapy
Background: High-dose rifampicin is considered to shorten anti-TB treatment duration but its effect on antiretroviral metabolism is unknown.

Objectives: To assess the effect o...

Health care workers' perceptions of point-of-care testing in a low-income country--a qualitative study in Southwestern Uganda

Rasti R, Nanjebe D, Karlstrom J, Muchunguzi C, Mwanga-Amumpaire J,  et al.
2017-07-27 • PLOS One
2017-07-27 • PLOS One
Point-of-care (POC) tests have become increasingly available and more widely used in recent years. They have been of particular importance to low-income settings, enabling them with clin...

Aetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda

Page AL, Kemigisha E, Salez N, Nanjebe D, Langendorf C,  et al.
2017-06-02 • Scientific Reports
2017-06-02 • Scientific Reports
Infections of the central nervous system (CNS) are severe conditions, leading to neurological sequelae or death. Knowledge of the causative agents is essential to develop guidelines for ...

Risk factors for vaginal colonization and relationship between bacterial vaginal colonization and in-hospital outcomes in women with obstructed labor in a Ugandan regional referral hospital

Ngonzi J, Bebell LM, Bazira J, Fajardo Y, Nyehangane D,  et al.
2018-09-20 • International Journal of Microbiology
2018-09-20 • International Journal of Microbiology
INTRODUCTION
The proportion of women with severe maternal morbidity from obstructed labor is between 2 and 12% in resource-limited settings. Maternal vaginal colonization with group ...