Search Results | MSF Science Portal

Journal Article

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Research

Rasti R, Kumbakumba E, Nanjebe D, Mlotshwa P, Nassejje M, et al.

2025-03-22 • BMC Infectious Diseases

BACKGROUND

In low-resource settings, limited laboratory capacity adds to the burden of central nervous system (CNS) infections in children and spurs overuse of ...

Journal Article

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Research

Kimathi D, Juan-Giner A, Bob NS, Orindi B, Namulwana ML, et al.

2025-02-20 • New England Journal of Medicine

BACKGROUND

Yellow fever vaccine is highly effective with a single dose, but vaccine supply is limited. The minimum dose requirements for seroconversion remain u...

Journal Article

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Research

Melingui BF, Basant J, Taguebue Jv, Massom DM, Leroy Terquem E, et al.

2024-11-03 • Journal of Tropical Medicine

OBJECTIVES

Chest x‐ray (CXR) plays an important role in childhood tuberculosis (TB) diagnosis, but access to quality CXR remains a major challenge in resource‐l...

Journal Article

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Research

Mwanga-Amumpaire J, Adong J, Arinaitwe R, Nanjebe D, Orikiriza P, et al.

2024-08-27 • BMC Pregnancy and Childbirth

BACKGROUND

Deaths ...

Journal Article

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Research

Wobudeya E, Nanfuka M, Ton Nu Nguyet MH, Taguebue JV, Moh R, et al.

2024-03-21 • ACG Case Reports Journal

BACKGROUND
Childhood tuberculosis (TB) remains underdiagnosed largely because of limited awareness and poor access to all or any of specimen collection, molecular testing, clinical e...

Journal Article

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Research

Joshi B, De Lima YV, Massom DM, Kaing S, Banga MF, et al.

2023-10-11 • PLOS Global Public Health

Decentralizing childhood tuberculosis services, including diagnosis, is now recommended by the WHO and could contribute to increasing tuberculosis detection in high burden countries. How...

Journal Article

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Research

Chupradit S, Wamalwa DC, Maleche-Obimbo E, Kekitiinwa AR, Mwanga-Amumpaire J, et al.

2023-10-05 • Journal of the Pediatric Infectious Diseases Society

BACKGROUND
The pharmacokinetics of abacavir (ABC) in African children living with HIV (CLHIV) weighing < 14 kg and receiving pediatric fixed dose combinations (FDC) according to WHO ...

Journal Article

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Research

Juan-Giner A, Namulwana ML, Kimathi D, Grantz KH, Fall G, et al.

2023-04-28 • Lancet Infectious Diseases

BACKGROUND
Current supply shortages constrain yellow fever vaccination activities, particularly outbreak response. Although fractional doses of all WHO-prequalified yellow fever vacc...

Journal Article

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Commentary

Chowdhury M, Ouma J, Nakabembe E, Mwanga-Amumpaire J, Kirenga B, et al.

2023-04-24 • Lancet Infectious Diseases

Journal Article

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Research

Bonnet MMB, Nordholm AC, Ssekyanzi B, Byamukama O, Orikiriza P, et al.

2023-03-23 • Pediatrics

BACKGROUND AND OBJECTIVES:
Children experience high tuberculosis (TB)-related mortality but causes of death among those with presumptive TB are poorly documented. We describe the mor...

Journal Article

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Research

Marcy O, Wobudeya E, Font H, Vessière A, Chabala C, et al.

2023-03-01 • Lancet Infectious Diseases

BACKGROUND
Tuberculosis diagnosis might be delayed or missed in children with severe pneumonia because this diagnosis is usually only considered in cases of prolonged symptoms or ant...

Journal Article

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Research

Rotsaert A, Ogara C, Mwanga-Amumpaire J, Kekitiinwa AR, Musiime V, et al.

2023-01-01 • Therapeutic Advances in Infectious Disease

BACKGROUND
Worldwide, 1.7 million children younger than 15 years were living with HIV in 2021. Only 52% of them had access to antiretrovirals (ARVs). Lack of age-appropriate ARV form...

Journal Article

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Research

Ardizzoni E, Orikiriza P, Ssuuna C, Nyehangane D, Gumsboga M, et al.

2019-10-16 • Journal of Clinical Microbiology

Background: Xpert MTB/RIF (Xpert) and culture are the most reliable methods for tuberculosis diagnosis but are still poorly accessible in many low resource countries. We aimed to assess ...

Journal Article

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Research

Oyet C, Roh ME, Kiwanuka G, Orikiriza P, Wade M, et al.

2017-10-28 • Malaria Journal

BACKGROUND
Early diagnosis of suspected malaria cases with a rapid diagnostic test (RDT) has been shown to be an effective malaria control tool used in many resource-constrained sett...

Journal Article

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Research

Loarec A, Carnimeo V, Molfino L, Kizito W, Muyindike WR, et al.

2018-11-16 • AIDS

: A multicentric, retrospective case-series analysis (facility-based) in five sites across Kenya, Malawi, Mozambique, and Uganda screened HIV-positive adults for hepatitis C virus (HCV) ...

Journal Article

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Research

le Polain de Waroux O, Flasche S, Kucharski AJ, Langendorf C, Ndazima D, et al.

2018-12-01 • Epidemics

Although patterns of social contacts are believed to be an important determinant of infectious disease transmission, it remains unclear how the frequency and nature of human interactions...

Journal Article

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Research

Boum Y II, Kim S, Orikiriza P, Acuña-Villaorduña C, Vinhas S, et al.

2016-03-30 • Journal of Clinical Microbiology

Sputum acid-fast bacilli (AFB) smear microscopy has suboptimal sensitivity but remains the most commonly used laboratory test to diagnose pulmonary tuberculosis (TB). We prospectively ev...

Journal Article

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Research

le Polain de Waroux O, Cohuet S, Ndazima D, Kucharski AJ, Juan-Giner A, et al.

2018-04-11 • BMC Infectious Diseases

BACKGROUND
Quantification of human interactions relevant to infectious disease transmission through social contact is central to predict disease dynamics, yet data from low-resource ...

Journal Article

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Research

Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, et al.

2010-11-08 • Lancet

Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice...

Journal Article

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Research

Orikiriza P, Nansumba M, Nyehangane D, Bastard M, Mugisha IT, et al.

2018-05-08 • European Journal of Clinical Microbiology and Infectious Diseases

The Xpert MTB/RIF assay is a major advance for diagnosis of tuberculosis (TB) in high-burden countries but is limited in children by their difficulty to produce sputum. We investigated T...

Science Portal

Clinical utility of the FilmArray® meningitis/encephalitis panel in children with suspected central nervous system infection in a low-resource setting – a prospective study in southwestern Uganda

Low-dose yellow fever vaccine in adults in Africa

Implementation of digital chest radiography for childhood tuberculosis diagnosis at district hospital level in six high tuberculosis burden and resources limited countries

Impact of postpartum maternal fever or hypothermia on newborn and early infant illness and death in Southwestern Uganda

Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study

Acceptability of decentralizing childhood tuberculosis diagnosis in low-income countries with high tuberculosis incidence: Experiences and perceptions from health care workers in Sub-Saharan Africa and South-East Asia

Abacavir drug exposures in African children under 14 kg using paediatric solid fixed dose combinations according to World Health Organization weight bands

Immunogenicity and safety of fractional doses of 17D-213 yellow fever vaccine in children (YEFE): a randomised, double-blind, non-inferiority substudy of a phase 4 trial

Strengthening the maternal and child health responses to Ebola outbreaks in Uganda

Mortality and cause of death in children with presumptive disseminated tuberculosis

Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Acceptability of a new 4-in-1 Abacavir/Lamivudine/Lopinavir/Ritonavir paediatric fixed-dose combination: the caregiver–child dyads’ perspective

Evaluation of OMNIgene® SPUTUM and ethanol reagent for preservation of sputum prior to Xpert and culture testing in Uganda

Evaluation of the Deki Reader™, an automated RDT reader and data management device, in a household survey setting in low malaria endemic southwestern Uganda

Extremely Low Hepatitis C prevalence among HIV co-infected individuals in 4 countries in sub-Saharan Africa

Identifying human encounters that shape transmission of Streptococcus pneumoniae and other acute respiratory infections

Diagnostic accuracy of the small membrane filtration method for diagnosis of pulmonary tuberculosis in a high HIV prevalence setting

Characteristics of human encounters and social mixing patterns relevant to infectious diseases spread by close contact: a survey in Southwest Uganda

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

Xpert MTB/RIF diagnosis of childhood tuberculosis from sputum and stool samples in a high TB-HIV-prevalent setting