Broger T, Koeppel L, Huerga H, Miller P, Gupta-Wright A, et al.
2023-06-01 • Lancet Global Health
2023-06-01 • Lancet Global Health
BACKGROUND Sputum is the most widely used sample to diagnose active tuberculosis, but many people living with HIV are unable to produce sputum. Urine, in contrast, is readily availab...
Griesel R, Zhao Y, Simmons B, Omar Z, Wiesner L, et al.
2023-05-22 • Lancet HIV
2023-05-22 • Lancet HIV
BACKGROUND The drug-drug interaction between rifampicin and dolutegravir can be overcome by supplemental dolutegravir dosing, which is difficult to implement in high-burden settings....
Rangaka MX, Wilkinson KA, Seldon R, van Cutsem G, Meintjes GA, et al.
2007-12-07 • American Journal of Respiratory and Critical Care Medicine
2007-12-07 • American Journal of Respiratory and Critical Care Medicine
RATIONALE: Two forms of the IFN-gamma release assay (IFNGRA) to detect tuberculosis infection are available, but neither has been evaluated in comparable HIV-infected and uninfected pers...
Osler M, Hilderbrand K, Goemaere E, Ford NP, Smith M, et al.
2018-03-04 • Clinical Infectious Diseases
2018-03-04 • Clinical Infectious Diseases
BACKGROUND Antiretroviral treatment (ART) has been massively scaled up to decrease human immunodeficiency virus (HIV)-related morbidity, mortality, and HIV transmission. However, des...
Ndjeka N, Campbell JR, Meintjes GA, Maartens G, Schaaf HS, et al.
2022-05-02 • Lancet Infectious Diseases
2022-05-02 • Lancet Infectious Diseases
BACKGROUND There is a need for short and safe all-oral treatment of rifampicin-resistant tuberculosis. We compared outcomes up to 24 months after treatment initiation for patients wi...
Ford NP, Meintjes GA, Pozniak A, Bygrave H, Hill AM, et al.
2014-11-19 • Lancet Infectious Diseases
2014-11-19 • Lancet Infectious Diseases
For more than two decades, CD4 cell count measurements have been central to understanding HIV disease progression, making important clinical decisions, and monitoring the response to ant...
Ismail N, Omar SV, Moultrie H, Bhyat Z, Conradie F, et al.
2021-11-12 • Lancet Infectious Diseases
2021-11-12 • Lancet Infectious Diseases
BACKGROUND Bedaquiline improves outcomes of patients with rifampicin-resistant and multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this success. We did...
Ndjeka N, Hughes J, Reuter A, Conradie F, Enwerem M, et al.
2020-10-01 • International Journal of Tuberculosis and Lung Disease
2020-10-01 • International Journal of Tuberculosis and Lung Disease
Worldwide uptake of new drugs in the treatment of rifampicin-resistant tuberculosis (RR-TB) has been extremely low. In June 2018, ahead of the release of the updated WHO guidelines for t...
Saranchuk P, Boulle AM, Hilderbrand K, Coetzee D, Bedelu M, et al.
2007-07-01 • South African Medical Journal
2007-07-01 • South African Medical Journal
OBJECTIVES: To evaluate the diagnostic accuracy of and reduction in diagnostic delay attributable to a clinical algorithm used for the diagnosis of smear-negative pulmonary tuberculosis ...
Shroufi A, Govender NP, Meintjes GA, Black JM, Nel J, et al.
2020-06-01 • International Journal of Infectious Diseases
2020-06-01 • International Journal of Infectious Diseases
BACKGROUND Cryptococcal Meningitis (CM) is estimated to cause 181,000 deaths annually; with the majority occurring in Sub Saharan Africa. Flucytosine is recommended by the World Heal...
Ndjeka N, Schnippel K, Master I, Meintjes GA, Maartens G, et al.
2018-10-25 • European Respiratory Journal
2018-10-25 • European Respiratory Journal
Background: South African patients with rifampicin-resistant tuberculosis and resistance to fluoroquinolones and/or injectables (pre/XDR-TB) were granted access to bedaquiline through a ...
Schnippel K, Ndjeka N, Maartens G, Meintjes GA, Master I, et al.
2018-09-01 • Lancet Respiratory Medicine
2018-09-01 • Lancet Respiratory Medicine
Addition of bedaquiline to treatment for multidrug-resistant tuberculosis was associated with an increased risk of death in a phase 2b clinical trial, resulting in caution from WHO. Foll...
Ndjeka N, Conradie F, Meintjes GA, Reuter A, Hughes J, et al.
2020-07-23 • European Respiratory Journal
2020-07-23 • European Respiratory Journal
Rapid adoption of new diagnostic tools, parallel process of research and implementation, decentralisation of services, the use of personal protective equipment, as well as strong partner...
