Journal Article > LetterFull Text
Emerg Infect Dis. 1 April 2008; Volume 14 (Issue 4); 681-683.; DOI:10.3201/eid1404.070833
Escribà JM, Nakoune E, Recio C, Massamba PM, Matsika-Claquin MD, et al.
Emerg Infect Dis. 1 April 2008; Volume 14 (Issue 4); 681-683.; DOI:10.3201/eid1404.070833
Journal Article > ResearchFull Text
Trans R Soc Trop Med Hyg. 1 December 2006; Volume 100 (Issue 12); DOI:10.1016/j.trstmh.2006.02.007
Bercion R, Accou-Demartin M, Recio C, Massamba PM, Frank T, et al.
Trans R Soc Trop Med Hyg. 1 December 2006; Volume 100 (Issue 12); DOI:10.1016/j.trstmh.2006.02.007
Shigella dysenteriae type 1 (Sd1) represents a particular threat in developing countries because of the severity of the infection and its epidemic potential. Antimicrobial susceptibility testing and molecular subtyping by pulsed-field gel electrophoresis (PFGE) and plasmid profiling (PP) of Sd1 isolates collected during two dysentery outbreaks (2013 and 445 cases of bloody diarrhoea) in Central African Republic (CAR) during the period 2003-2004 were reported. Eleven Sd1 comparison strains (CS) acquired by travellers or residents of Africa (n=10) or Asia (n=1) between 1993 and 2003 were also analysed. The 19 Sd1 isolates recovered from CAR outbreaks were multidrug resistant, although susceptible to quinolones and fluoroquinolones. Molecular subtyping by PFGE was more discriminatory than PP. The PFGE using XbaI and NotI restriction enzymes indicated that the two outbreaks were due to two different clones and also revealed a genetic diversity among the CS recovered from outbreak or sporadic cases between 1993 and 2003. This study was the result of a fruitful collaboration between field physicians and microbiologists. The data collected will serve as the basis for establishing long-term monitoring of Sd1 in CAR.