Journal Article > Commentary
PLOS Glob Public Health. 2022 December 30; Volume 2 (Issue 12); e0001431.; DOI:10.1371/journal.pgph.0001431
Martinez Garcia D, Amsalu R, Harkensee C, Janet S, Kadir A, et al.
PLOS Glob Public Health. 2022 December 30; Volume 2 (Issue 12); e0001431.; DOI:10.1371/journal.pgph.0001431
Journal Article > CommentarySubscription Only
Med J Aust. 2014 May 1; Volume 200 (Issue 9); 512-512.; DOI:10.5694/mja14.00143
Martinez Garcia D, Brown AL
Med J Aust. 2014 May 1; Volume 200 (Issue 9); 512-512.; DOI:10.5694/mja14.00143
Journal Article > Case Report/SeriesFull Text
Oxf Med Case Reports. 2019 September 1; Volume 2019 (Issue 9); omz090.; DOI:10.1093/omcr/omz090
Bottineau MC, Kouevi KA, Chauvet E, Martinez Garcia D, Galetto-Lacour A, et al.
Oxf Med Case Reports. 2019 September 1; Volume 2019 (Issue 9); omz090.; DOI:10.1093/omcr/omz090
INTRODUCTION
Tuberculosis is a common illness for vulnerable populations in resource-limited settings. Lymph nodes in tuberculosis represent the most frequent extra-pulmonary form of tuberculosis in children, but lymph nodes are rarely generalized and large. We report an atypical pediatric case of tuberculosis with lymphadenopathy.
PATIENT CONCERNS AND FINDINGS
A two-year-old child with severe acute malnutrition presented with painless, generalized, and excessively large nodes which were not compressive and were without fistula. Main diagnoses, interventions, outcomes: Fine needle aspiration was performed and led to the detection of lymph node granulomatous lymphadenitis suggestive of tuberculosis.
CONCLUSIONS
The child was immediately initiated on anti-tuberculosis therapy with a very successful outcome. Clinicians should be aware of atypical manifestations such as the one we describe in the interest of swift diagnosis and initiation of treatment.
Tuberculosis is a common illness for vulnerable populations in resource-limited settings. Lymph nodes in tuberculosis represent the most frequent extra-pulmonary form of tuberculosis in children, but lymph nodes are rarely generalized and large. We report an atypical pediatric case of tuberculosis with lymphadenopathy.
PATIENT CONCERNS AND FINDINGS
A two-year-old child with severe acute malnutrition presented with painless, generalized, and excessively large nodes which were not compressive and were without fistula. Main diagnoses, interventions, outcomes: Fine needle aspiration was performed and led to the detection of lymph node granulomatous lymphadenitis suggestive of tuberculosis.
CONCLUSIONS
The child was immediately initiated on anti-tuberculosis therapy with a very successful outcome. Clinicians should be aware of atypical manifestations such as the one we describe in the interest of swift diagnosis and initiation of treatment.
Conference Material > Poster
Papadimitriou V, Ciglenecki I, Gonzalez A, Macher E, Martinez Garcia D, et al.
MSF Scientific Days UK 2018: Research. 2018 May 14; DOI:10.7490/f1000research.1115457.1
Journal Article > ResearchFull Text
Front Public Health. 2014 December 8; Volume 2; DOI:10.3389/fpubh.2014.00266
Martinez Garcia D, Bonnardot L, Olson D, Roggeveen H, Karsten J, et al.
Front Public Health. 2014 December 8; Volume 2; DOI:10.3389/fpubh.2014.00266
We conducted a retrospective analysis of all pediatric cases referred by Médecins Sans Frontières (MSF) field doctors via the MSF telemedicine system during a 4-year period from April 2010. A total of 467 pediatric cases were submitted, representing approximately 40% of all telemedicine cases. The median age of the patients was 4 years. The median response time (i.e., the interval between the case being submitted and the first response from a specialist) was 13 h (interquartile range 4-32 h). We selected a random sample of 12 pediatric cases in each of four age categories for detailed analysis by an experienced MSF pediatrician. In the 48 randomly selected cases, the mean rating for the quality of information provided by the referrer was 2.8 (on a scale from 1 = very poor to 5 = very good), and the mean rating for the appropriateness of the response was 3.3 (same scale). More than two-thirds of the responses were considered to be useful to the patient, and approximately three-quarters were considered to be useful to the medical team. The usefulness of the responses tended to be higher for the medical team than for the patient, and there was some evidence that usefulness to both groups was lower in newborns and adolescent patients. The telemedicine system allows the quality of the medical support given to medical teams in the field to be controlled objectively as there is a record of all cases and answers. Telemedicine has an important role in supporting the aims of medical humanitarian organizations such as MSF.
Journal Article > ReviewFull Text
Front Nutr. 2016 June 14; Volume 3; 16.; DOI:10.3389/fnut.2016.00016
Hiffler L, Rakotoambinina B, Lafferty N, Martinez Garcia D
Front Nutr. 2016 June 14; Volume 3; 16.; DOI:10.3389/fnut.2016.00016
In humans, thiamine is a micronutrient prone to depletion that may result in severe clinical abnormalities. This narrative review summarizes current knowledge on thiamine deficiency (TD) and bridges the gap between pathophysiology and clinical presentation by integrating thiamine metabolism at subcellular level with its function to vital organs. The broad clinical spectrum of TD is outlined, with emphasis on conditions encountered in tropical pediatric practice. In particular, TD is associated with type B lactic acidosis and classic forms of beriberi in children, but it is often unrecognized. Other severe acute conditions are associated with hypermetabolism, inducing a functional TD. The crucial role of thiamine in infant cognitive development is also highlighted in this review, along with analysis of the potential impact of TD in refeeding syndrome during severe acute malnutrition (SAM). This review aims to increase clinical awareness of TD in tropical settings where access to diagnostic tests is poor, and advocates for an early therapeutic thiamine challenge in resource-limited settings. Moreover, it provides evidence for thiamine as treatment in critical conditions requiring metabolic resuscitation, and gives rationale to the consideration of increased thiamine supplementation in therapeutic foods for malnourished children.