Journal Article > LetterFull Text
Rev Soc Bras Med Trop. 2018 December 31; Volume 52; DOI:10.1590/0037-8682-0262-2018
Forsyth C, Marchiol A, Herazo R, Chatelain E, Batista C, et al.
Rev Soc Bras Med Trop. 2018 December 31; Volume 52; DOI:10.1590/0037-8682-0262-2018
Journal Article > ResearchFull Text
Trans R Soc Trop Med Hyg. 2008 October 4; Volume 103 (Issue 2); DOI:10.1016/j.trstmh.2008.09.001
Roddy P, Marchiol A, Jeffs B, Palma PP, Bernal O, et al.
Trans R Soc Trop Med Hyg. 2008 October 4; Volume 103 (Issue 2); DOI:10.1016/j.trstmh.2008.09.001
In 2005, a Marburg haemorrhagic fever (MHF) outbreak occurred in Uíge province, Angola, which had its epicentre in Uíge municipality. Concurrently, a health facility located a considerable distance from the outbreak's epicentre reported a drastic reduction in attendance, possibly due to a remote effect of the ongoing MHF outbreak. Health officials should devise strategies to ensure that communities far from a filovirus haemorrhagic fever epicentre are not adversely affected by interventions at the epicentre and, to the greatest extent possible, ensure that these peripheral communities receive essential medical care during an epidemic.
Journal Article > ResearchFull Text
Mem Inst Oswaldo Cruz. 2009 November 1; Volume 104 (Issue 7); DOI:10.1590/S0074-02762009000700008
Escriba JM, Ponce E, Romero Ade D, Albajar Viñas P, Marchiol A, et al.
Mem Inst Oswaldo Cruz. 2009 November 1; Volume 104 (Issue 7); DOI:10.1590/S0074-02762009000700008
Between 1999-2002, Médécins Sans Frontières-Spain implemented a project seeking to determine the efficacy and safety of benznidazole in the treatment of recent chronic Chagas disease in a cohort of seropositive children in the Yoro Department, Honduras. A total of 24,471 children were screened for Trypanosoma cruzi IgG antibodies through conventional enzyme-linked immunosorbent assays (ELISA) on filter paper. Recombinant ELISA (0.93% seroprevalence) showed 256 initially reactive cases, including 232 confirmed positive cases. Of these, 231 individuals were treated with benznidazole (7.5 mg/kg/day) for 60 days and were followed with a strict weekly medical control and follow-up protocol. At the end of the project, 229 patients were examined by the Honduras Secretariat of Health for post-treatment serological assessments; 88.2% seroconverted after 18 months and 93.9% seroconverted after three years. No differences were found in the seroconversion rates according to age or sex. Most of the side effects of the treatment were minor. These results support the argument that in areas where T. cruzi I is predominant and in areas affected by T. cruzi II, when vector transmission has been interrupted, Chagas disease diagnosis and treatment are feasible, necessary and ethically indisputable.
Journal Article > CommentaryFull Text
PLoS Negl Trop Dis. 2017 January 5; Volume 11 (Issue 1); e0005148.; DOI:10.1371/journal.pntd.0005148
Picado A, Angheben A, Marchiol A, Alarcón de Noya B, Flevaud L, et al.
PLoS Negl Trop Dis. 2017 January 5; Volume 11 (Issue 1); e0005148.; DOI:10.1371/journal.pntd.0005148