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v2.1.5153.produseast1
Showing 1 - 19 of 19 Items
Showing 1 - 19 of 19 Items
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Journal Article
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Research

Cholera outbreaks in sub-Saharan Africa during 2010-2019: a descriptive analysis

Zheng Q, Luquero FJ, Ciglenecki I, Wamala JF, Abubakar A,  et al.
2022-09-01 • International Journal of Infectious Diseases
2022-09-01 • International Journal of Infectious Diseases
BACKGROUND
Cholera remains a public health threat but is inequitably distributed across sub-Saharan Africa. Lack of standardized reporting and inconsistent outbreak definitions limit...
Journal Article
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Research

Successive epidemic waves of cholera in South Sudan between 2014 and 2017: a descriptive epidemiological study

Jones FK, Wamala JF, Rumunu J, Mawien PN, Kol MT,  et al.
2020-12-01 • Lancet Planetary health
2020-12-01 • Lancet Planetary health
Background
Between 2014 and 2017, successive cholera epidemics occurred in South Sudan within the context of civil war, population displacement, flooding, and drought. We aim to des...
Journal Article
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Research

Immune responses to an oral cholera vaccine in internally displaced persons in South Sudan

Iyer AS, Ryan ET, Martin S, Legros D, Lessler J,  et al.
2016-10-24 • Scientific Reports
2016-10-24 • Scientific Reports
Despite recent large-scale cholera outbreaks, little is known about the immunogenicity of oral cholera vaccines (OCV) in African populations, particularly among those at highest cholera ...
Journal Article
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Research

Effectiveness of one dose of oral cholera vaccine in response to an outbreak: a case-cohort study

Azman AS, Parker LA, Rumunu J, Tadesse F, Grandesso F,  et al.
2016-11-01 • Lancet Global Health
2016-11-01 • Lancet Global Health
BACKGROUND
Oral cholera vaccines represent a new effective tool to fight cholera and are licensed as two-dose regimens with 2-4 weeks between doses. Evidence from previous studies su...
Journal Article
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Commentary

What is a hotspot anyway?

Lessler J, Azman AS, McKay H, Moore SM
2017-06-01 • American Journal of Tropical Medicine and Hygiene
2017-06-01 • American Journal of Tropical Medicine and Hygiene
The importance of spatial clusters, or "hotspots," in infectious disease epidemiology has been increasingly recognized, and targeting hotspots is often seen as an important component of ...
Journal Article
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Research

Mapping the burden of cholera in sub-Saharan Africa and implications for control: an analysis of data across geographical scales

Lessler J, Moore SM, Luquero FJ, McKay H, Grais RF,  et al.
2018-05-01 • Lancet
2018-05-01 • Lancet
Cholera remains a persistent health problem in sub-Saharan Africa and worldwide. Cholera can be controlled through appropriate water and sanitation, or by oral cholera vaccination, which...
Journal Article
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Commentary

Oral cholera vaccine in cholera prevention and control, Malawi

Mbangombe M, Pezzoli L, Reeder B, Kabuluzi S, Msyamboza K,  et al.
2018-06-01 • Bulletin of the World Health Organization
2018-06-01 • Bulletin of the World Health Organization
PROBLEM
With limited global supplies of oral cholera vaccine, countries need to identify priority areas for vaccination while longer-term solutions, such as water and sanitation infr...
Journal Article
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Research

The seasonality of cholera in sub-Saharan Africa: a statistical modelling study

Perez-Saez J, Lessler J, Lee EC, Luquero FJ, Malembaka EB,  et al.
2022-04-21 • Lancet Global Health
2022-04-21 • Lancet Global Health
BACKGROUND
Cholera remains a major threat in sub-Saharan Africa (SSA), where some of the highest case-fatality rates are reported. Knowing in what months and where cholera tends to o...
Journal Article
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Review

Clinical and epidemiological aspects of diphtheria: a systematic review and pooled analysis

Truelove SA, Keegan LT, Moss WJ, Chaisson LH, Macher E,  et al.
2019-08-19 • Clinical Infectious Diseases
2019-08-19 • Clinical Infectious Diseases
BACKGROUND
Diphtheria, once a major cause of childhood morbidity and mortality, all but disappeared following introduction of diphtheria vaccine. Recent outbreaks highlight the risk ...
Journal Article
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Research

El Niño and the shifting geography of cholera in Africa

Moore SM, Azman AS, Zaitchik BF, Mintz ED, Brunkard J,  et al.
2017-04-10 • Proceedings of the National Academy of Sciences
2017-04-10 • Proceedings of the National Academy of Sciences
The El Niño Southern Oscillation (ENSO) and other climate patterns can have profound impacts on the occurrence of infectious diseases ranging from dengue to cholera. In Africa, El Niño c...
Journal Article
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Commentary

The first use of the global oral cholera vaccine emergency stockpile: Lessons from South Sudan

Abubakar A, Azman AS, Rumunu J, Ciglenecki I, Helderman T,  et al.
2015-11-17 • PLOS Medicine
2015-11-17 • PLOS Medicine
SUMMARY POINTS

• A global oral cholera vaccine (OCV) stockpile was established in 2013 to improve rapid access to the vaccine in outbreaks and emergencies in which cholera risk...
Journal Article
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Research

Regional sequencing collaboration reveals persistence of the T12 Vibrio cholerae O1 lineage in West Africa

Ekeng E, Tchatchouang S, Akenji B, Issaka B, Akintayo I,  et al.
2021-06-18 • eLife
2021-06-18 • eLife
BACKGROUND
Despite recent insights into cholera transmission patterns in Africa, regional and local dynamics in West Africa-where cholera outbreaks occur every few years-are still po...
Journal Article
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Research

High hepatitis E seroprevalence among displaced persons in South Sudan

Azman AS, Bouhenia M, Iyer AS, Rumunu J, Laku R,  et al.
2017-06-07 • American Journal of Tropical Medicine and Hygiene
2017-06-07 • American Journal of Tropical Medicine and Hygiene

Large protracted outbreaks of hepatitis E virus (HEV) have been documented in displaced populations in Africa over the past decade though data are limited outside these exceptional se...

Journal Article
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Letter

Outbreaks of cholera in the time of Ebola: pre-emptive action needed

Azman AS, Legros D, Lessler J, Luquero FJ, Moore SM
2015-02-19 • Lancet
2015-02-19 • Lancet
Journal Article
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Review

Protection against cholera from killed whole-cell oral cholera vaccines: a systematic review and meta-analysis

Bi Q, Ferreras E, Pezzoli L, Legros D, Ivers LI,  et al.
2017-07-17 • Lancet Infectious Diseases
2017-07-17 • Lancet Infectious Diseases
Journal Article
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Research

Micro-hotspots of risk in urban cholera epidemics

Azman AS, Lugero FJ, Salje H, Naibei N, Adalbert N,  et al.
2018-05-11 • Journal of Infectious Diseases
2018-05-11 • Journal of Infectious Diseases
Targeted interventions have been delivered to neighbors of cholera cases in major epidemic responses globally despite limited evidence for the impact of such targeting. Using data from u...
Journal Article
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Research

Urban Cholera transmission hotspots and their implications for Reactive Vaccination: evidence from Bissau city, Guinea Bissau

Azman AS, Luquero FJ, Rodrigues A, Palma PP, Grais RF,  et al.
2012-11-08 • PLOS Neglected Tropical Diseases
2012-11-08 • PLOS Neglected Tropical Diseases
Use of cholera vaccines in response to epidemics (reactive vaccination) may provide an effective supplement to traditional control measures. In Haiti, reactive vaccination was considered...
Journal Article
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Research

The impact of a one-dose versus two-dose oral cholera vaccine regimen in outbreak settings: a modeling study

Azman AS, Luquero FJ, Ciglenecki I, Grais RF, Sack DA,  et al.
2015-08-25 • PLOS Medicine
2015-08-25 • PLOS Medicine
BACKGROUND
In 2013, a stockpile of oral cholera vaccine (OCV) was created for use in outbreak response, but vaccine availability remains severely limited. Innovative strategies are n...
Journal Article
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Research

Population-level effect of cholera vaccine on displaced populations, South Sudan, 2014

Azman AS, Rumunu J, Abubakar A, West H, Ciglenecki I,  et al.
2016-06-01 • Emerging Infectious Diseases
2016-06-01 • Emerging Infectious Diseases
Following mass population displacements in South Sudan, preventive cholera vaccination campaigns were conducted in displaced persons camps before a 2014 cholera outbreak. We compare chol...