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Showing 1 - 20 of 60 Items
Showing 1 - 20 of 60 Items
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Journal Article
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Research

Intravenous rehydration for severe acute malnutrition with gastroenteritis

Maitland K, Ouattara SM, Sainna H, Chara A, Ogundipe OF,  et al.
2025-06-13 • New England Journal of Medicine
2025-06-13 • New England Journal of Medicine

BACKGROUND

International recommendations advise against the use of intravenous rehydration therapy in children with severe acute malnutrition because of the con...

Journal Article
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Research

Effect of mass campaigns with full and fractional doses of pneumococcal conjugate vaccine (Pneumosil) on the reduction of nasopharyngeal pneumococcal carriage in Niger: a three-arm, open-label, cluster-randomised trial

Coldiron ME, Soumana I, Baudin E, Langendorf C, Mamiafo Tchoula C,  et al.
2025-01-08 • Lancet Infectious Diseases
2025-01-08 • Lancet Infectious Diseases

BACKGROUND

In settings with low pneumococcal conjugate vaccine (PCV) coverage, multi-age cohort mass campaigns could increase population immunity, and fractiona...

Technical Report
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Policy Brief

Joint brief: The Lancet Countdown on Health and Climate Change & Médecins Sans Frontières

Voûte C, Baker H, Baidjoe AY, Bartrem C, Charrier M,  et al.
2024-10-29
2024-10-29

At the time of writing, many people around the world are feeling the pain, disruption, and devastating health consequences driven by climate change. The world has been shocked by the ...

Conference Material
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Poster

Local cumulative antimicrobial susceptibility report: results from MSF pediatrics and surgical programs

Langendorf C, Michel J, Barks P, Mollo B, Kanapathipillai R
2024-05-23 • Epicentre Scientific Day 2024
2024-05-23 • Epicentre Scientific Day 2024
Conference Material
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Abstract

Measles confirmation and seroprevalence: addressing the challenges of sample collection and laboratory procedures

Langendorf C, Nikolay B
2024-05-23 • Epicentre Scientific Day 2024
2024-05-23 • Epicentre Scientific Day 2024
BACKGROUND
While case confirmation is most of the time not necessary for case management decisions– the measles outbreak response relies on the timely biological confirmation of outb...
Conference Material
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Poster

Measles seroprevalence after repeated epidemics and reactive vaccination campaigns in Magaria and Mirriah, Niger in 2023

Mamaty AA, Atti S, Sani KA, Tonamou G, Ciglenecki I,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
Journal Article
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Research

Prescribing practices in the treatment of wasting: secondary analysis from a randomised trial

Rattigan SM, Grantz KH, Hanson K, Langendorf C, Berthé F,  et al.
2024-02-26 • BMJ Nutrition, Prevention & Health
2024-02-26 • BMJ Nutrition, Prevention & Health
INTRODUCTION
Current guidelines for the outpatient treatment of severe acute malnutrition (SAM) recommend the provision of routine medications to all children at admission and prescr...
Journal Article
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Protocol

Gastroenteritis rehydration of children with severe acute malnutrition (GASTROSAM): A phase II randomised controlled trial: Trial protocol

Olupot-Olupot P, Aloroker F, Mpoya A, Mnjalla H, Paasi G,  et al.
2024-01-16 • Wellcome Open Research
2024-01-16 • Wellcome Open Research

BACKGROUND

Chi...

Journal Article
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Research

Effect of amoxicillin on the gut microbiome of children with severe acute malnutrition in Madarounfa, Niger: a retrospective metagenomic analysis of a placebo-controlled trial

Schwartz DJ, Langdon A, Sun X, Langendorf C, Berthé F,  et al.
2023-10-19 • Lancet Microbe
2023-10-19 • Lancet Microbe
BACKGROUND
Children with severe acute malnutrition are treated with antibiotics as outpatients. We aimed to determine the effect of 7 days of amoxicillin on acute and long-term chang...
Journal Article
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Research

Practices and challenges related to antibiotic use in paediatric treatment in hospitals and health centres in Niger and Uganda: a mixed methods study

Mambula G, Nanjebe D, Munene A, Guindo O, Salifou A,  et al.
2023-07-11 • Antimicrobial Resistance and Infection Control
2023-07-11 • Antimicrobial Resistance and Infection Control
BACKGROUND
Antibiotic resistance is a significant public health problem and is responsible for high mortality in children and new-borns. Strengthening the rational use of antibiotics...
Journal Article
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Research

Faecal carriage of extended-spectrum ß-lactamase-producing Escherichia coli in a remote region of Niger

Jacquier H, Assao B, Chau F, Guindo O, Condamine B,  et al.
2023-06-25 • Journal of Infection
2023-06-25 • Journal of Infection
OBJECTIVE
Whole genome sequencing (WGS) of extended-spectrum ß-lactamase-producing Escherichia coli (ESBL-E. coli) in developing countries is lacking. Here we describe the population...
Conference Material
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Abstract

Invasive bacterial infections in patients with advanced HIV disease in Kinshasa: prevalence, antibiotic resistance and treatment

Langendorf C
2023-06-08 • Epicentre Scientific Day Paris 2023
2023-06-08 • Epicentre Scientific Day Paris 2023
BACKGROUND
Patients with advanced HIV disease (AHD), defined as WHO clinical stage 3 or 4 and/or CD4<200, have a high risk of death. One common cause of death is invasive bacterial i...
Conference Material
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Video

Invasive bacterial infections in patients with advanced HIV disease in Kinshasa: prevalence, antibiotic resistance and treatment

Langendorf C
2023-06-08 • Epicentre Scientific Day Paris 2023
2023-06-08 • Epicentre Scientific Day Paris 2023
Journal Article
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Research

Validation of three MicroScan® antimicrobial susceptibility testing plates designed for low-resource settings

Ronat JB, Oueslati S, Natale A, Kesteman T, Elamin W,  et al.
2022-08-30 • Diagnostics
2022-08-30 • Diagnostics
Easy and robust antimicrobial susceptibility testing (AST) methods are essential in clinical bacteriology laboratories (CBL) in low-resource settings (LRS). We evaluated the Beckman Coul...
Journal Article
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Research

Evaluation of OMNIgene® SPUTUM and ethanol reagent for preservation of sputum prior to Xpert and culture testing in Uganda

Ardizzoni E, Orikiriza P, Ssuuna C, Nyehangane D, Gumsboga M,  et al.
2019-10-16 • Journal of Clinical Microbiology
2019-10-16 • Journal of Clinical Microbiology
Background: Xpert MTB/RIF (Xpert) and culture are the most reliable methods for tuberculosis diagnosis but are still poorly accessible in many low resource countries. We aimed to assess ...
Journal Article
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Research

Intrahousehold management and use of nutritional supplements during the hunger gap in Maradi region, Niger: a qualitative study

Marquer C, Langendorf C, Woi-Messe LC, Berthé F, Ategbo EA,  et al.
2020-03-03 • BMC Nutrition
2020-03-03 • BMC Nutrition
BACKGROUND
Nutritional supplements are used for preventing and treating childhood malnutrition. While there is a growing body of evidence on product efficacy, less emphasis has been ...
Journal Article
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Research

Measles seroprevalence after reactive vaccination campaigns during the 2015 measles outbreak in four health zones of the former Katanga Province, Democratic Republic of Congo

Keating P, Carrion Martin AI, Blake A, Lechevalier P, Uzzeni F,  et al.
2019-08-22 • BMC Public Health
2019-08-22 • BMC Public Health
BACKGROUND:
Measles continues to circulate in the Democratic Republic of Congo, and the country suffered from several important outbreaks over the last 5 years. Despite a large outb...
Journal Article
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Research

Identifying human encounters that shape transmission of Streptococcus pneumoniae and other acute respiratory infections

le Polain de Waroux O, Flasche S, Kucharski AJ, Langendorf C, Ndazima D,  et al.
2018-12-01 • Epidemics
2018-12-01 • Epidemics
Although patterns of social contacts are believed to be an important determinant of infectious disease transmission, it remains unclear how the frequency and nature of human interactions...
Journal Article
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Research

Immunogenicity of an oral rotavirus vaccine administered with prenatal nutritional support in Niger: A cluster randomized clinical trial

Isanaka S, Garba S, Plikaytis BD, McNeal MM, Guindo O,  et al.
2021-08-10 • PLOS Medicine
2021-08-10 • PLOS Medicine
BACKGROUND
Nutritional status may play a role in infant immune development. To identify potential boosters of immunogenicity in low-income countries where oral vaccine efficacy is lo...
Journal Article
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Research

Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Grais RF, Laminou IM, Woi-Messe LC, Makarimi R, Bouriema SH,  et al.
2018-02-27 • Malaria Journal
2018-02-27 • Malaria Journal
BACKGROUND
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) w...