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Research

Risk stratification of childhood infection using host markers of immune and endothelial activation in Asia (Spot Sepsis): a multi-country, prospective, cohort study

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Van Anh DT,  et al.
2025-09-01 • Lancet Child and Adolescent Health
2025-09-01 • Lancet Child and Adolescent Health

BACKGROUND

Prognostic tools for febrile illnesses are urgently required in resource-constrained community contexts. Circulating immune and endothelial activatio...

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Derivation and validation of prognostic models for the risk stratification of childhood infection: a multi-country prospective cohort study in Asia (Spot-Sepsis)

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Anh DTV,  et al.
2025-02-05 • MSF Scientific Days International 2025
2025-02-05 • MSF Scientific Days International 2025

Derivation and validation of prognostic models for the risk stratification of childhood infection: a multi-country prospective cohort study in Asia (Spot-Sepsis)

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Anh DTV,  et al.
2025-02-05 • MSF Scientific Days International 2025
2025-02-05 • MSF Scientific Days International 2025

Risk stratification of childhood infection using host markers of immune and endothelial activation: A multi-country prospective cohort study in Asia (Spot Sepsis)

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Anh DTV,  et al.
2025-02-05 • medRxiv
2025-02-05 • medRxiv

BACKGROUND

Circulating markers of immune and endothelial activation risk stratify infection syndromes agnostic to disease aetiology. However, their utility in c...

Point-of-care prognostication in moderate Covid-19: Analytical validation and prognostic accuracy of a soluble urokinase plasminogen activator receptor (suPAR) rapid test

Chandna A, Mahajan R, Gautam P, Mwandigha L, Dittrich S,  et al.
2023-08-21 • PLOS Global Public Health
2023-08-21 • PLOS Global Public Health
The soluble urokinase plasminogen activator receptor (suPAR) has been proposed as a biomarker for risk stratification of patients presenting with acute infections. However, most studies ...

Facilitating safe discharge through predicting disease progression in moderate COVID-19: development and validation of a prediction model in resource-limited settings

Chandna A, PRIORITISE Study Group, Mahajan R, Gautam P, Mwandigha L,  et al.
2022-05-09 • MSF Scientific Days International 2022
2022-05-09 • MSF Scientific Days International 2022
INTRODUCTION
In locations where few people have received Covid-19 vaccines, health systems remain vulnerable to spikes in SARS-CoV-2 infections. Triage tools, which could include bio...

Facilitating safe discharge through predicting disease progression in moderate COVID-19: a prospective cohort study to develop and validate a clinical prediction model in resource-limited settings

Chandna A, Mahajan R, Gautam P, Mwandigha L, Gunasekaran K,  et al.
2022-03-21 • Clinical Infectious Diseases
2022-03-21 • Clinical Infectious Diseases
BACKGROUND
In locations where few people have received COVID-19 vaccines, health systems remain vulnerable to surges in SARS-CoV-2 infections. Tools to identify patients suitable for...

Prediction of disease severity in young children presenting with acute febrile illness in resource-limited settings: a protocol for a prospective observational study

Chandna A, Aderie EM, Ahmad R, Arguni E, Ashley EA,  et al.
2021-01-25 • BMJ Open
2021-01-25 • BMJ Open
INTRODUCTION
In rural and difficult-to-access settings, early and accurate recognition of febrile children at risk of progressing to serious illness could contribute to improved pati...