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Copyright © Médecins Sans Frontières
v2.1.5153.produseast1
Showing 1 - 16 of 16 Items
Showing 1 - 16 of 16 Items
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Journal Article
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Research

An automated literature review tool (LiteRev) for streamlining and accelerating research using natural language processing and machine learning: Descriptive performance evaluation study

Orel EB, Ciglenecki I, Thiabaud A, Temerev A, Calmy A,  et al.
2023-09-15 • ACG Case Reports Journal
2023-09-15 • ACG Case Reports Journal
BACKGROUND
Literature reviews (LRs) identify, evaluate, and synthesize relevant papers to a particular research question to advance understanding and support decision-making. However...
Journal Article
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Research

Monitoring of antiretroviral therapy and mortality in HIV programmes in Malawi, South Africa and Zambia: mathematical modelling study

Estill J, Egger M, Johnson LF, Gsponer T, Wandeler G,  et al.
2013-02-28 • PLOS One
2013-02-28 • PLOS One
OBJECTIVES
Mortality in patients starting antiretroviral therapy (ART) is higher in Malawi and Zambia than in South Africa. We examined whether different monitoring of ART (viral loa...
Journal Article
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Research

Variability of growth in children starting antiretroviral treatment in Southern Africa

Gsponer T, Weigel R, Davies MA, Bolton C, Moultrie H,  et al.
2012-09-17 • Pediatrics
2012-09-17 • Pediatrics
BACKGROUND
Poor growth is an indication for antiretroviral therapy (ART) and a criterion for treatment failure. We examined variability in growth response to ART in 12 programs in Ma...
Journal Article
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Research

Mortality in patients with HIV-1 infection starting antiretroviral therapy in South Africa, Europe, or North America: a collaborative analysis of prospective studies

Boulle AM, Schomaker M, May MT, Hogg RS, Shepherd B,  et al.
2014-09-09 • PLOS Medicine
2014-09-09 • PLOS Medicine
BACKGROUND
High early mortality in patients with HIV-1 starting antiretroviral therapy (ART) in sub-Saharan Africa, compared to Europe and North America, is well documented. Longer-t...
Journal Article
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Research

Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa

Fenner L, Brinkhof MW, Keiser O, Weigel R, Cornell M,  et al.
2010-08-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2010-08-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
BACKGROUND: Many HIV-infected children in Southern Africa have been started on antiretroviral therapy (ART), but loss to follow up (LTFU) can be substantial. We analyzed mortality in chi...
Journal Article
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Research

Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring

Keiser O, Tweya H, Boulle AM, Braitstein P, Schechter M,  et al.
2009-09-10 • AIDS
2009-09-10 • AIDS
BACKGROUND
In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring ...
Journal Article
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Research

Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies

Johnson LF, Mossong J, Dorrington R, Schomaker M, Hoffman CJ,  et al.
2013-04-09 • PLOS Medicine
2013-04-09 • PLOS Medicine
Few estimates exist of the life expectancy of HIV-positive adults receiving antiretroviral treatment (ART) in low- and middle-income countries. We aimed to estimate the life expectancy o...
Journal Article
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Research

Risk charts to guide targeted HIV-1 viral load monitoring of ART: development and validation in patients from resource-limited settings

Koller M, Fatti G, Chi BH, Keiser O, Hoffman CJ,  et al.
2015-07-07 • Journal of Acquired Immune Deficiency Syndromes (1999)
2015-07-07 • Journal of Acquired Immune Deficiency Syndromes (1999)
Journal Article
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Research

Zidovudine impairs immunological recovery on first-line antiretroviral therapy: collaborative analysis of cohort studies in southern Africa

Wandeler G, Gsponer T, Mulenga L, Garone DB, Wood R,  et al.
2013-09-01 • AIDS
2013-09-01 • AIDS
OBJECTIVES
Zidovudine (ZDV) is recommended for first-line antiretroviral therapy (ART) in resource-limited settings. ZDV may, however, lead to anemia and impaired immunological respo...
Journal Article
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Research

Viral load versus CD4⁺ monitoring and 5-year outcomes of antiretroviral therapy in HIV-positive children in Southern Africa: a cohort-based modelling study

Salazar-Vizcaya L, Keiser O, Technau KG, Davies MA, Haas AD,  et al.
2014-10-23 • AIDS
2014-10-23 • AIDS
OBJECTIVES
Many paediatric antiretroviral therapy (ART) programmes in Southern Africa rely on CD4⁺ to monitor ART. We assessed the benefit of replacing CD4⁺ by viral load monitoring....
Journal Article
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Research

The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure

Davies MA, Boulle AM, Technau KG, Eley B, Moultrie H,  et al.
2012-09-01 • Tropical Medicine and International Health
2012-09-01 • Tropical Medicine and International Health
OBJECTIVES
To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV-infected children on antiretroviral ...
Journal Article
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Research

Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration

Davies MA, Moultrie H, Eley B, Rabie H, van Cutsem G,  et al.
2011-03-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2011-03-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
With expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determ...
Journal Article
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Research

Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared

Keiser O, Orrell C, Egger M, Wood R, Brinkhof MW,  et al.
2008-07-08 • PLOS Medicine
2008-07-08 • PLOS Medicine
BACKGROUND: The provision of highly active antiretroviral therapy (HAART) in resource-limited settings follows a public health approach, which is characterised by a limited number of reg...
Journal Article
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Research

Outcomes of the South African National Antiretroviral Treatment Programme for children: the IeDEA Southern Africa collaboration

Davies MA, Keiser O, Technau KG, Eley B, Rabie H,  et al.
2009-10-01 • South African Medical Journal
2009-10-01 • South African Medical Journal
OBJECTIVES: To assess paediatric antiretroviral treatment (ART) outcomes and their associations from a collaborative cohort representing 20% of the South African national treatment progr...
Journal Article
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Research

Accuracy of immunological criteria for identifying virological failure in children on antiretroviral therapy - The IeDEA Southern Africa Collaboration

Davies MA, Boulle AM, Eley B, Moultrie H, Technau KG,  et al.
2011-08-11 • Tropical Medicine and International Health
2011-08-11 • Tropical Medicine and International Health
Objectives  To determine the diagnostic accuracy of World Health Organization (WHO) 2010 and 2006 as well as United States Department of Health and Human Services (DHHS) 2008 definitions...
Journal Article
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Research

Viral Load Monitoring of Antiretroviral Therapy, cohort viral load and HIV transmission in Southern Africa: A Mathematical Modelling Analysis

Estill J, Aubriere C, Egger M, Johnson LF, Wood R,  et al.
2012-03-20 • AIDS
2012-03-20 • AIDS
In low-income settings, treatment failure is often identified using CD4 cell count monitoring. Consequently, patients remain on a failing regimen, resulting in a higher risk of transmiss...