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Research

Targeting CD4 testing to a clinical subgroup of patients could limit unnecessary CD4 measurements, premature antiretroviral treatment and costs in Thyolo District, Malawi

Zachariah R, Teck R, Ascurra O, Humblet P, Harries AD
2006-01-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2006-01-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Malawi offers antiretroviral treatment (ART) to all HIV-positive adults who are clinically classified as being in WHO clinical stage III or IV without 'universal' CD4 testing. This study...
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Implementing Joint TB and HIV Interventions in a Rural District of Malawi: Is There a Role for an International Non-Governmental Organisation?

Zachariah R, Teck R, Harries AD, Humblet P
2004-09-01 • International Journal of Tuberculosis and Lung Disease
2004-09-01 • International Journal of Tuberculosis and Lung Disease
In a rural district in Malawi, poorly motivated health personnel, shortages of human and financial resources, weak dialogue between existing tuberculosis (TB) and human immunodeficiency ...

Community support is associated with better antiretroviral treatment outcomes in a resource-limited rural district in Malawi

Zachariah R, Teck R, Buhendwa L, Fitzerland M, Labana S,  et al.
2007-01-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2007-01-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
A study was carried in a rural district in Malawi among HIV-positive individuals placed on antiretroviral treatment (ART) in order to verify if community support influences ART outcomes....

Treatment Outcomes Stratified by Baseline Immunological Status Among Young Children Receiving Nonnucleoside Reverse-Transcriptase Inhibitor-Based Antiretroviral Therapy in Resource-Limited Settings

O'Brien DP, Sauvageot D, Olson D, Schaeffer M, Humblet P,  et al.
2007-05-01 • Clinical Infectious Diseases
2007-05-01 • Clinical Infectious Diseases
A study of 568 children aged <5 years who commenced nonnucleoside reverse-transcriptase inhibitor-based antiretroviral therapy in resource-limited settings revealed good early outcomes. ...

In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy

O'Brien DP, Sauvageot D, Zachariah R, Humblet P
2006-10-03 • AIDS
2006-10-03 • AIDS
OBJECTIVES
To (a) determine early treatment outcomes and (b) assess safety in children treated with adult fixed-dose combination (FDC) antiretroviral tablets.

SETTING
S...

WHO Clinical Staging of HIV Infection and Disease, Tuberculosis and Eligibility for Antiretroviral Treatment: Relationship to CD4 Lymphocyte Counts

Teck R, Ascurra O, Gomani P, Manzi M, Pasulani O,  et al.
2005-03-01 • International Journal of Tuberculosis and Lung Disease
2005-03-01 • International Journal of Tuberculosis and Lung Disease
SETTING: Thyolo district, Malawi. OBJECTIVES: To determine in HIV-positive individuals aged over 13 years CD4 lymphocyte counts in patients classified as WHO Clinical Stage III and IV an...

Can We Get More HIV-Positive Tuberculosis Patients on Antiretroviral Treatment in a Rural District of Malawi?

Zachariah R, Teck R, Ascurra O, Gomani P, Manzi M,  et al.
2005-03-01 • International Journal of Tuberculosis and Lung Disease
2005-03-01 • International Journal of Tuberculosis and Lung Disease
The World Health Organization (WHO) has set a target of treating 3 million people with antiretroviral treatment (ART) by 2005. In sub-Saharan Africa, HIV-positive tuberculosis (TB) patie...

High acceptability of voluntary counselling and HIV-testing but unacceptable loss to follow up in a prevention of mother-to-child HIV transmission programme in rural Malawi: scaling-up requires a different way of acting

Manzi M, Zachariah R, Teck R, Buhendwa L, Kazima J,  et al.
2005-12-01 • Tropical Medicine and International Health
2005-12-01 • Tropical Medicine and International Health
SETTING: Thyolo District Hospital, rural Malawi. OBJECTIVES: In a prevention of mother-to-child HIV transmission (PMTCT) programme, to determine: the acceptability of offering 'opt-out' ...

Passive Versus Active Tuberculosis Case Finding and Isoniazid Preventive Therapy Among Household Contacts in a Rural District of Malawi

Zachariah R, Spielmann M P, Harries AD, Gomani P, Graham SM,  et al.
2003-11-01 • International Journal of Tuberculosis and Lung Disease
2003-11-01 • International Journal of Tuberculosis and Lung Disease
SETTING: Thyolo district, rural Malawi. OBJECTIVES: To compare passive with active case finding among household contacts of smear-positive pulmonary tuberculosis (TB) patients for 1) TB ...

Second-line antiretroviral therapy in resource-limited settings: the experience of Médecins Sans Frontières

Pujades-Rodríguez M, O'Brien DP, Humblet P, Calmy A
2008-07-11 • AIDS
2008-07-11 • AIDS
OBJECTIVES: To describe the use of second-line protease-inhibitor regimens in Médecins Sans Frontières HIV programmes, and determine switch rates, clinical outcomes, and factors associat...