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Research

Effect of caregiver training on knowledge and confidence of at-home clinical and anthropometric surveillance of children with uncomplicated severe acute malnutrition: analysis of a cross-over cluster randomised trial in Sokoto, Nigeria

Ali NB, Hitchings MD, Berthé F, Aruna P, Shehu I,  et al.
2025-10-01 • BMJ Global Health
2025-10-01 • BMJ Global Health

INTRODUCTION

Patient-centred task-shifting models may be a promising strategy in the community-based management of severe acute malnutrition (SAM) to alleviate ...

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Journal Article
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Research

Effectiveness of a monthly schedule of follow-up for the treatment of uncomplicated severe acute malnutrition in Sokoto, Nigeria: a cluster randomized crossover trial

Hitchings MD, Berthe F, Aruna P, Shehu I, Ali Hamza M,  et al.
2022-03-01 • PLOS Medicine
2022-03-01 • PLOS Medicine
BACKGROUND
Community-based management of severe acute malnutrition (SAM) involves weekly or biweekly outpatient clinic visits for clinical surveillance and distribution of therapeuti...

Humoral and cellular immune response induced by rVSVΔG-ZEBOV-GP vaccine among frontline workers during the 2013-2016 West Africa Ebola outbreak in Guinea

Juan-Giner A, Hitchings MD, Soumah A, Strecker T, Sadjo M,  et al.
2020-06-01 • Vaccine
2020-06-01 • Vaccine
Background
As part of a Phase III trial with the Ebola vaccine rVSVΔG-ZEBOV-GP in Guinea, we invited frontline workers (FLWs) to participate in a sub-study to provide additional inf...

Using Simulation to Aid Trial Design: Ring-Vaccination Trials

Hitchings MD, Grais RF, Lipsitch M
2017-03-22 • PLOS Neglected Tropical Diseases
2017-03-22 • PLOS Neglected Tropical Diseases
The 2014-6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based ...

A mixture model to assess the the immunogenicity of an oral rotavirus vaccine among healthy infants in Niger

Hitchings MD, Cummings DAT, Grais RF, Isanaka S
2020-12-03 • Vaccine
2020-12-03 • Vaccine
Analysis of immunogenicity data is a critical component of vaccine development, providing a biological basis to support any observed protection from vaccination. Conventional methods for...

Single-dose oral ciprofloxacin prophylaxis as a response to a meningococcal meningitis epidemic in the African meningitis belt: A 3-arm, open-label, cluster-randomized trial

Coldiron ME, Assao B, Page AL, Hitchings MD, Alcoba G,  et al.
2018-06-26 • PLOS Medicine
2018-06-26 • PLOS Medicine
Antibiotic prophylaxis for contacts of meningitis cases is not recommended during outbreaks in the African meningitis belt. We assessed the effectiveness of single-dose oral ciprofloxaci...

Ciprofloxacin for contacts of cases of meningococcal meningitis as an epidemic response: study protocol for a cluster-randomized trial

Coldiron ME, Alcoba G, Ciglenecki I, Hitchings MD, Djibo A,  et al.
2017-06-24 • Trials
2017-06-24 • Trials
Epidemics of meningococcal meningitis are common in the "African meningitis belt." Current response strategies include reactive vaccination campaigns, which are often organized too late ...

Cost-effectiveness of monthly follow-up for the treatment of uncomplicated severe acute malnutrition: An economic evaluation of a randomized controlled trial

Menzies NA, Berthé F, Hitchings MD, Aruna P, Hamza MA,  et al.
2022-12-09 • PLOS Global Public Health
2022-12-09 • PLOS Global Public Health
Severe acute malnutrition (SAM) is a major source of mortality for children in low resource settings. Alternative treatment models that improve acceptability and reduce caregiver burden ...