Journal Article > Case Report/SeriesFull Text
Pan Afr Med J. 24 August 2020; Volume 36; 330.; DOI:10.11604/pamj.2020.36.330.24512
Frank T, Gil Cuesta J, Mbecko JR, Sanke H, Lakis C, et al.
Pan Afr Med J. 24 August 2020; Volume 36; 330.; DOI:10.11604/pamj.2020.36.330.24512
Bacteria of the Burkholderia cepacia complex cause frequent infections in immunocompromised and hospitalized patients, with a significant mortality rate. Phenotypic identification of those bacteria is difficult and therefore rarely reported from developing countries. This study presents the first ever reported case series of Burkholderia cenocepacia neonatal sepsis in Central African Republic. It demonstrates the superiority of molecular methods to accurately identify B. cenocepacia IIIA species compared to the phenotypic methods.
Journal Article > ResearchFull Text
Trans R Soc Trop Med Hyg. 1 December 2006; Volume 100 (Issue 12); DOI:10.1016/j.trstmh.2006.02.007
Bercion R, Accou-Demartin M, Recio C, Massamba PM, Frank T, et al.
Trans R Soc Trop Med Hyg. 1 December 2006; Volume 100 (Issue 12); DOI:10.1016/j.trstmh.2006.02.007
Shigella dysenteriae type 1 (Sd1) represents a particular threat in developing countries because of the severity of the infection and its epidemic potential. Antimicrobial susceptibility testing and molecular subtyping by pulsed-field gel electrophoresis (PFGE) and plasmid profiling (PP) of Sd1 isolates collected during two dysentery outbreaks (2013 and 445 cases of bloody diarrhoea) in Central African Republic (CAR) during the period 2003-2004 were reported. Eleven Sd1 comparison strains (CS) acquired by travellers or residents of Africa (n=10) or Asia (n=1) between 1993 and 2003 were also analysed. The 19 Sd1 isolates recovered from CAR outbreaks were multidrug resistant, although susceptible to quinolones and fluoroquinolones. Molecular subtyping by PFGE was more discriminatory than PP. The PFGE using XbaI and NotI restriction enzymes indicated that the two outbreaks were due to two different clones and also revealed a genetic diversity among the CS recovered from outbreak or sporadic cases between 1993 and 2003. This study was the result of a fruitful collaboration between field physicians and microbiologists. The data collected will serve as the basis for establishing long-term monitoring of Sd1 in CAR.
Journal Article > ResearchFull Text
Emerg Infect Dis. 1 September 2018; Volume 24 (Issue 9); DOI:10.3201/eid2409.171058
Coldiron ME, Touré OA, Frank T, Bouygues N, Grais RF
Emerg Infect Dis. 1 September 2018; Volume 24 (Issue 9); DOI:10.3201/eid2409.171058
We report a pneumococcal meningitis outbreak in the Central African Republic (251 suspected cases; 60 confirmed by latex agglutination test) in 2016-2017. Case-fatality rates (10% for confirmed case-patients) were low. In areas where a recent pneumococcal conjugate vaccine campaign was conducted, a smaller proportion of cases was seen in youngest children.