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Copyright © Médecins Sans Frontières
v2.1.5153.produseast1
Showing 1 - 12 of 12 Items
Showing 1 - 12 of 12 Items
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Journal Article
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Research

Diagnostic performance and usability of the VISITECT CD4 semi-quantitative test for advanced HIV disease screening

Ndlovu Z, Massaquoi L, Bangwen NE, Batumba JN, Bora RU,  et al.
2020-04-03 • PLOS One
2020-04-03 • PLOS One
BACKGROUND
In sub-Saharan Africa, a third of people starting antiretroviral therapy and majority of patients returning to HIV-care after disengagement, present with advanced HIV dise...
Journal Article
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Research

Implementing the Xpert MTB/RIF diagnostic test for tuberculosis and rifampicin resistance: outcomes and lessons learned in 18 countries

Ardizzoni E, Fajardo E, Saranchuk P, Casenghi M, Page AL,  et al.
2015-12-15 • PLOS One
2015-12-15 • PLOS One
BACKGROUND
The Xpert® MTB/RIF (Xpert) is an automated molecular test for simultaneous detection of tuberculosis (TB) and rifampicin resistance, recommended by the World Health Organi...
Journal Article
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Research

Errors generated by a point-of-care CD4+ T-lymphocyte analyser: a retrospective observational study in nine countries

Fajardo E, Metcalf CJ, Piriou E, Gueguen M, Maman D,  et al.
2015-06-25 • Bulletin of the World Health Organization
2015-06-25 • Bulletin of the World Health Organization
OBJECTIVE
To estimate the proportion of invalid results generated by a CD4+ T-lymphocyte analyser used by Médecins Sans Frontières (MSF) in field projects and identify factors associ...
Journal Article
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Research

Field suitability and diagnostic accuracy of the Biocentric open real-time PCR platform for plasma-based HIV viral load quantification in Swaziland

Mpala Q, Maphalala G, Uribe PAD, de la Tour R, Kalombola S,  et al.
2018-11-14 • BMC Infectious Diseases
2018-11-14 • BMC Infectious Diseases
Viral load (VL) testing is being scaled up in resource-limited settings. However, not all commercially available VL testing methods have been evaluated under field conditions. This study...
Journal Article
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Research

Field suitability and diagnostic accuracy of the Biocentric open real-time PCR platform for dried blood spot-based HIV viral load quantification in Eswatini

Kerschberger B, Ntshalintshali N, Mpala Q, Diaz Uribe PA, Maphalala G,  et al.
2019-09-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2019-09-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
BACKGROUND
To assess the performance and suitability of dried blood spot (DBS) sampling using filter paper to collect blood for viral load (VL) quantification under routine condition...
Journal Article
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Review

Challenges and opportunities for the implementation of virological testing in resource-limited settings

Roberts TR, Bygrave H, Fajardo E, Ford NP
2012-10-09 • Journal of the International AIDS Society
2012-10-09 • Journal of the International AIDS Society
Though the advantages of routine virological monitoring for patients on anti-retroviral therapy have been established, cost and complexity limit its full implementation. Monitoring is im...
Journal Article
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Research

Pooled HIV-1 Viral Load Testing Using Dried Blood Spots to Reduce the Cost of Monitoring Antiretroviral Treatment in a Resource-Limited Setting

Pannus P, Fajardo E, Metcalf CJ, Coulborn R M, Duran LT,  et al.
2013-07-25 • Journal of Acquired Immune Deficiency Syndromes (1999)
2013-07-25 • Journal of Acquired Immune Deficiency Syndromes (1999)
: Rollout of routine HIV-1 viral load monitoring is hampered by high costs and logistical difficulties associated with sample collection and transport. New strategies are needed to overc...
Journal Article
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Research

Detecting tuberculosis: rapid tools but slow progress

England K, Masini T, Fajardo E
2019-09-21 • Public Health Action
2019-09-21 • Public Health Action
The World Health Organization (WHO) currently recommends Xpert® MTB/RIF as the initial test for all people with presumptive tuberculosis (TB). A number of challenges have been reported, ...
Journal Article
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Research

Multidisease testing for HIV and TB using the GeneXpert platform: A feasibility study in rural Zimbabwe

Ndlovu M, Fajardo E, Mbofana F, Maparo TMS, Garone DB,  et al.
2018-03-02 • PLOS One
2018-03-02 • PLOS One
HIV Viral Load and Early Infant Diagnosis technologies in many high burden settings are restricted to centralized laboratory testing, leading to long result turnaround times and patient ...
Journal Article
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Commentary

Framework for the implementation of advanced HIV disease diagnostics in sub-Saharan Africa: programmatic perspectives

Ndlovu Z, Burton R, Stewart RC, Bygrave H, Roberts TR,  et al.
2020-05-27 • Lancet HIV
2020-05-27 • Lancet HIV
Journal Article
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Research

Expanding Access to HIV Viral Load Testing: A Systematic Review of RNA Stability in EDTA Tubes and PPT beyond Current Time and Temperature Thresholds

Bonner K, Siemieniuk R, Boozary A, Roberts TR, Fajardo E,  et al.
2014-12-01 • PLOS One
2014-12-01 • PLOS One
HIV viral load (VL) testing is the gold standard for antiretroviral treatment monitoring, but many barriers exist to VL testing in resource-limited settings, including storage and transp...
Journal Article
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Research

Opportunities to improve storage and transportation of blood specimens for CD4 testing in a rural district in Zimbabwe using BD vacutainer CD4 stabilization tubes: a stability and diagnostic accuracy study

Fajardo E, Metcalf CJ, Mbofana F, van Vyve C, Munyaradzi D,  et al.
2014-10-22 • BMC Infectious Diseases
2014-10-22 • BMC Infectious Diseases
BackgroundCD4+ T-cell testing of blood specimens collected in standard EDTA Vacutainer tubes and transported at ambient temperature, must be completed within 48 hours with the BD FACSCou...