Chihana M, Conan N, Ohler L, Huerga H, Wanjala S, et al.
2024-06-17 • Journal of the International Association of Providers of AIDS Care
2024-06-17 • Journal of the International Association of Providers of AIDS Care
BACKGROUND The burden of advanced HIV disease remains a significant concern in sub-Saharan Africa. In 2015, the World Health Organization released recommendations to treat all people...
Fenner L, Atkinson A, Boulle AM, Fox MP, Prozesky HW, et al.
2017-06-23 • Journal of the International AIDS Society
2017-06-23 • Journal of the International AIDS Society
Chronic immune activation due to ongoing HIV replication may lead to impaired immune responses against opportunistic infections such as tuberculosis (TB). We studied the role of HIV repl...
Estill J, Egger M, Johnson LF, Gsponer T, Wandeler G, et al.
2013-02-28 • PLOS One
2013-02-28 • PLOS One
OBJECTIVES Mortality in patients starting antiretroviral therapy (ART) is higher in Malawi and Zambia than in South Africa. We examined whether different monitoring of ART (viral loa...
Cornell M, Technau KG, Fairall L, Wood R, Moultrie H, et al.
2009-09-01 • South African Medical Journal
2009-09-01 • South African Medical Journal
OBJECTIVES: To introduce the combined South African cohorts of the International epidemiologic Databases to Evaluate AIDS Southern Africa (IeDEA-SA) collaboration as reflecting the South...
BACKGROUND Poor growth is an indication for antiretroviral therapy (ART) and a criterion for treatment failure. We examined variability in growth response to ART in 12 programs in Ma...
Davies MA, Tsondai PR, Tiffin N, Eley B, Rabie H, et al.
2017-03-16 • Journal of the International AIDS Society
2017-03-16 • Journal of the International AIDS Society
To evaluate long-term outcomes in HIV-infected adolescents, it is important to identify ways of tracking outcomes after transfer to a different health facility. The Department of Health ...
Fenner L, Brinkhof MW, Keiser O, Weigel R, Cornell M, et al.
2010-08-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2010-08-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
BACKGROUND: Many HIV-infected children in Southern Africa have been started on antiretroviral therapy (ART), but loss to follow up (LTFU) can be substantial. We analyzed mortality in chi...
Schomaker M, Leroy V, Wolfs T, Technau KG, Renner L, et al.
2016-06-24 • International Journal of Epidemiology
2016-06-24 • International Journal of Epidemiology
Background: There is limited knowledge about the optimal timing of antiretroviral treatment initiation in older children and adolescents. Methods: A total of 20 576 antiretroviral treatm...
Ford NP, Meintjes GA, Pozniak A, Bygrave H, Hill AM, et al.
2014-11-19 • Lancet Infectious Diseases
2014-11-19 • Lancet Infectious Diseases
For more than two decades, CD4 cell count measurements have been central to understanding HIV disease progression, making important clinical decisions, and monitoring the response to ant...
Green A, De Azevedo V, Patten GE, Davies MA, Ibeto M, et al.
2014-06-02 • PLOS One
2014-06-02 • PLOS One
To combat the AIDS epidemic and increase HIV treatment access, the South African government implemented a nurse-based, doctor-supported model of care that decentralizes administration of...
Fortuin-de Smidt M, de Waal R, Cohen K, Technau KG, Stinson K, et al.
2017-02-13 • PLOS One
2017-02-13 • PLOS One
There are a limited number of paediatric antiretroviral drug options. Characterising the long term safety and durability of different antiretrovirals in children is important to optimise...
2020-05-14 • Journal of the International AIDS Society
2020-05-14 • Journal of the International AIDS Society
Introduction
In South Africa, an estimated 4.6 million people were accessing antiretroviral therapy (ART) in 2018. As universal Test and Treat is implemented, these numbers will con...
OBJECTIVES Zidovudine (ZDV) is recommended for first-line antiretroviral therapy (ART) in resource-limited settings. ZDV may, however, lead to anemia and impaired immunological respo...
BACKGROUND:
In resource-limited settings holding regimens, such as lamivudine monotherapy (LM), are used to manage HIV-positive children failing combination antiretroviral therapy (...
Salazar-Vizcaya L, Keiser O, Technau KG, Davies MA, Haas AD, et al.
2014-10-23 • AIDS
2014-10-23 • AIDS
OBJECTIVES Many paediatric antiretroviral therapy (ART) programmes in Southern Africa rely on CD4⁺ to monitor ART. We assessed the benefit of replacing CD4⁺ by viral load monitoring....
2012-09-01 • Tropical Medicine and International Health
2012-09-01 • Tropical Medicine and International Health
OBJECTIVES To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV-infected children on antiretroviral ...
Davies MA, Moultrie H, Eley B, Rabie H, van Cutsem G, et al.
2011-03-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2011-03-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
With expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determ...
Nyakato P, Schomaker M, Sipambo N, Technau KG, Fatti G, et al.
2021-01-21 • AIDS
2021-01-21 • AIDS
Background and objectives:
Adolescents living with perinatally acquired HIV (ALPHIV) on antiretroviral therapy (ART) have been noted to have poorer adherence, retention and virolog...
Chihana ML, Huerga H, Van Cutsem G, Ellman T, Wanjala S, et al.
2018-11-26 • PLOS One
2018-11-26 • PLOS One
Background Latest WHO guidelines recommend starting HIV-positive individuals on antiretroviral therapy treatment (ART) regardless of CD4 count. We assessed additional impact of adopt...
