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Copyright © Médecins Sans Frontières
v2.1.5209.produseast1
Showing 1 - 20 of 30 Items
Showing 1 - 20 of 30 Items
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Journal Article
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Research

Changes over time in the proportion of advanced HIV disease in two high HIV prevalence settings in Ndhiwa (Kenya) and Eshowe (South Africa)

Chihana M, Conan N, Ohler L, Huerga H, Wanjala S,  et al.
2024-06-17 • Journal of the International Association of Providers of AIDS Care
2024-06-17 • Journal of the International Association of Providers of AIDS Care
BACKGROUND
The burden of advanced HIV disease remains a significant concern in sub-Saharan Africa. In 2015, the World Health Organization released recommendations to treat all people...
Journal Article
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Research

Advanced HIV disease and engagement in care among patients on antiretroviral therapy in South Africa: results from a multi-state model

Patten GE, Euvrard J, Anderegg N, Boulle AM, Arendse KD,  et al.
2022-11-24 • AIDS
2022-11-24 • AIDS
OBJECTIVE
Despite improved access to antiretroviral therapy (ART) for people with HIV (PWH), HIV continues to contribute considerably to morbidity and mortality. Increasingly, advanc...
Journal Article
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Research

HIV Viral Load as an Independent Risk Factor for Tuberculosis in South Africa: Collaborative Analysis of Cohort Studies

Fenner L, Atkinson A, Boulle AM, Fox MP, Prozesky HW,  et al.
2017-06-23 • Journal of the International AIDS Society
2017-06-23 • Journal of the International AIDS Society
Chronic immune activation due to ongoing HIV replication may lead to impaired immune responses against opportunistic infections such as tuberculosis (TB). We studied the role of HIV repl...
Journal Article
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Research

Monitoring of antiretroviral therapy and mortality in HIV programmes in Malawi, South Africa and Zambia: mathematical modelling study

Estill J, Egger M, Johnson LF, Gsponer T, Wandeler G,  et al.
2013-02-28 • PLOS One
2013-02-28 • PLOS One
OBJECTIVES
Mortality in patients starting antiretroviral therapy (ART) is higher in Malawi and Zambia than in South Africa. We examined whether different monitoring of ART (viral loa...
Journal Article
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Research

Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007: the IeDEA Southern Africa collaboration

Cornell M, Technau KG, Fairall L, Wood R, Moultrie H,  et al.
2009-09-01 • South African Medical Journal
2009-09-01 • South African Medical Journal
OBJECTIVES: To introduce the combined South African cohorts of the International epidemiologic Databases to Evaluate AIDS Southern Africa (IeDEA-SA) collaboration as reflecting the South...
Journal Article
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Research

Causes of hospital admission among people living with HIV worldwide: a systematic review and meta-analysis

Ford NP, Shubber Z, Meintjes GA, Grinsztejn B, Eholie SP,  et al.
2015-08-11 • Lancet HIV
2015-08-11 • Lancet HIV
Journal Article
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Research

Variability of growth in children starting antiretroviral treatment in Southern Africa

Gsponer T, Weigel R, Davies MA, Bolton C, Moultrie H,  et al.
2012-09-17 • Pediatrics
2012-09-17 • Pediatrics
BACKGROUND
Poor growth is an indication for antiretroviral therapy (ART) and a criterion for treatment failure. We examined variability in growth response to ART in 12 programs in Ma...
Journal Article
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Research

Where do HIV-infected adolescents go after transfer? - Tracking transition/transfer of HIV-infected adolescents using linkage of cohort data to a health information system platform

Davies MA, Tsondai PR, Tiffin N, Eley B, Rabie H,  et al.
2017-03-16 • Journal of the International AIDS Society
2017-03-16 • Journal of the International AIDS Society
To evaluate long-term outcomes in HIV-infected adolescents, it is important to identify ways of tracking outcomes after transfer to a different health facility. The Department of Health ...
Journal Article
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Research

Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa

Fenner L, Brinkhof MW, Keiser O, Weigel R, Cornell M,  et al.
2010-08-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2010-08-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
BACKGROUND: Many HIV-infected children in Southern Africa have been started on antiretroviral therapy (ART), but loss to follow up (LTFU) can be substantial. We analyzed mortality in chi...
Journal Article
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Research

Optimal Timing of Antiretroviral Treatment Initiation in HIV-Positive Children and Adolescents: a Multiregional Analysis from Southern Africa, West Africa and Europe

Schomaker M, Leroy V, Wolfs T, Technau KG, Renner L,  et al.
2016-06-24 • International Journal of Epidemiology
2016-06-24 • International Journal of Epidemiology
Background: There is limited knowledge about the optimal timing of antiretroviral treatment initiation in older children and adolescents. Methods: A total of 20 576 antiretroviral treatm...
Journal Article
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Commentary

The future role of CD4 cell count for monitoring antiretroviral therapy

Ford NP, Meintjes GA, Pozniak A, Bygrave H, Hill AM,  et al.
2014-11-19 • Lancet Infectious Diseases
2014-11-19 • Lancet Infectious Diseases
For more than two decades, CD4 cell count measurements have been central to understanding HIV disease progression, making important clinical decisions, and monitoring the response to ant...
Journal Article
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Research

Clinical mentorship of nurse initiated antiretroviral therapy in Khayelitsha, South Africa: a quality of care assessment

Green A, De Azevedo V, Patten GE, Davies MA, Ibeto M,  et al.
2014-06-02 • PLOS One
2014-06-02 • PLOS One
To combat the AIDS epidemic and increase HIV treatment access, the South African government implemented a nurse-based, doctor-supported model of care that decentralizes administration of...
Journal Article
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Research

First-Line Antiretroviral Drug Discontinuations in Children

Fortuin-de Smidt M, de Waal R, Cohen K, Technau KG, Stinson K,  et al.
2017-02-13 • PLOS One
2017-02-13 • PLOS One
There are a limited number of paediatric antiretroviral drug options. Characterising the long term safety and durability of different antiretrovirals in children is important to optimise...
Journal Article
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Research

Long-term virologic responses to antiretroviral therapy among HIV-positive patients entering adherence clubs in Khayelitsha, Cape Town, South Africa: a longitudinal analysis

Kehoe K, Boulle AM, Tsondai PR, Euvrard J, Davies MA,  et al.
2020-05-14 • Journal of the International AIDS Society
2020-05-14 • Journal of the International AIDS Society
Introduction
In South Africa, an estimated 4.6 million people were accessing antiretroviral therapy (ART) in 2018. As universal Test and Treat is implemented, these numbers will con...
Journal Article
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Research

Zidovudine impairs immunological recovery on first-line antiretroviral therapy: collaborative analysis of cohort studies in southern Africa

Wandeler G, Gsponer T, Mulenga L, Garone DB, Wood R,  et al.
2013-09-01 • AIDS
2013-09-01 • AIDS
OBJECTIVES
Zidovudine (ZDV) is recommended for first-line antiretroviral therapy (ART) in resource-limited settings. ZDV may, however, lead to anemia and impaired immunological respo...
Journal Article
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Research

Lamivudine monotherapy as a holding regimen for HIV-positive children

Patten GE, Bernheimer J, Fairlie L, Rabie H, Sawry S,  et al.
2018-10-11 • PLOS One
2018-10-11 • PLOS One
BACKGROUND:
In resource-limited settings holding regimens, such as lamivudine monotherapy (LM), are used to manage HIV-positive children failing combination antiretroviral therapy (...
Journal Article
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Research

Viral load versus CD4⁺ monitoring and 5-year outcomes of antiretroviral therapy in HIV-positive children in Southern Africa: a cohort-based modelling study

Salazar-Vizcaya L, Keiser O, Technau KG, Davies MA, Haas AD,  et al.
2014-10-23 • AIDS
2014-10-23 • AIDS
OBJECTIVES
Many paediatric antiretroviral therapy (ART) programmes in Southern Africa rely on CD4⁺ to monitor ART. We assessed the benefit of replacing CD4⁺ by viral load monitoring....
Journal Article
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Research

The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure

Davies MA, Boulle AM, Technau KG, Eley B, Moultrie H,  et al.
2012-09-01 • Tropical Medicine and International Health
2012-09-01 • Tropical Medicine and International Health
OBJECTIVES
To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV-infected children on antiretroviral ...
Journal Article
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Research

Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration

Davies MA, Moultrie H, Eley B, Rabie H, van Cutsem G,  et al.
2011-03-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2011-03-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
With expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determ...
Journal Article
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Research

Virologic response of adolescents living with perinatally acquired HIV receiving antiretroviral therapy in the period of early adolescence (10-14 years) in South Africa

Nyakato P, Schomaker M, Sipambo N, Technau KG, Fatti G,  et al.
2021-01-21 • AIDS
2021-01-21 • AIDS
Background and objectives:
Adolescents living with perinatally acquired HIV (ALPHIV) on antiretroviral therapy (ART) have been noted to have poorer adherence, retention and virolog...