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Copyright © Médecins Sans Frontières
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Showing 1 - 4 of 4 Items
Showing 1 - 4 of 4 Items
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Journal Article
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Research

Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study

Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E,  et al.
2011-04-19 • Lancet
2011-04-19 • Lancet
BACKGROUND: The Xpert MTB/RIF test (Cepheid, Sunnyvale, CA, USA) can detect tuberculosis and its multidrug-resistant form with very high sensitivity and specificity in controlled studies...
Journal Article
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Research

Impact of Xpert MTB/RIF for TB Diagnosis in a Primary Care Clinic with High TB and HIV Prevalence in South Africa: A Pragmatic Randomised Trial

Cox HS, Mbhele S, Mohess N, Whitelaw A, Muller O,  et al.
2014-11-25 • PLOS Medicine
2014-11-25 • PLOS Medicine
BACKGROUND
Xpert MTB/RIF is approved for use in tuberculosis (TB) and rifampicin-resistance diagnosis. However, data are limited on the impact of Xpert under routine conditions in se...
Journal Article
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Commentary

Diagnostic preparedness for infectious disease outbreaks

Perkins MD, Dye C, Balasegaram M, Brechot C, Mombouli JV,  et al.
2017-11-11 • Lancet
2017-11-11 • Lancet
Diagnostics are crucial in mitigating the effect of disease outbreaks. Because diagnostic development and validation are time consuming, they should be carried out in anticipation of epi...
Journal Article
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Short Report

Defining the Needs for Next Generation Assays for Tuberculosis

Denkinger CM, Kik S, Cirillo DM, Casenghi M, Shinnick T,  et al.
2015-04-01 • Journal of Infectious Diseases
2015-04-01 • Journal of Infectious Diseases
To accelerate the fight against tuberculosis, major diagnostic challenges need to be addressed urgently. Post-2015 targets are unlikely to be met without the use of novel diagnostics tha...