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Short communication: antituberculosis drug-induced hepatotoxicity is unexpectedly low in HIV-infected pulmonary tuberculosis patients in Malawi | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Short communication: antituberculosis drug-induced hepatotoxicity is unexpectedly low in HIV-infected pulmonary tuberculosis patients in Malawi

Tostmann A, Boeree M, Harries AD, Sauvageot D, Banda HT, Zijlstra EE
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Abstract
The proportion of patients with antituberculosis drug-induced hepatotoxicity (ATDH) was unexpectedly low during a trial on cotrimoxazole prophylaxis in Malawian HIV-positive pulmonary tuberculosis patients. About 2% of the patients developed grade 2 or 3 hepatotoxicity during tuberculosis (TB) treatment, according to WHO definitions. Data on ATDH in sub-Saharan Africa are limited. Although the numbers are not very strong, our trial and other papers suggest that ATDH is uncommon in this region. These findings are encouraging in that hepatotoxicity may cause less problem than expected, especially in the light of combined HIV/TB treatment, where drug toxicity is a major cause of treatment interruption.

Countries

Malawi

Subject Area

tuberculosis

Languages

English
DOI
10.1111/j.1365-3156.2007.01871.x
Published Date
01 Jul 2007
PubMed ID
17596252
Journal
Tropical Medicine and International Health
Volume | Issue | Pages
Volume 12, Issue 7
Issue Date
2007-06-25
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