logo
Science Portal
Copyright © Médecins Sans Frontières
v2.1.5153.produseast1
About MSF Science Portal
About
Contact Us
Frequently Asked Questions (FAQs)
Privacy Policy
Terms of Use
Copyright © Médecins Sans Frontières
v2.1.5153.produseast1
Evaluation of a new recombinant K39 rapid diagnostic test for Sudanese visceral leishmaniasis | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Evaluation of a new recombinant K39 rapid diagnostic test for Sudanese visceral leishmaniasis

Ritmeijer KKD, Melaku Y, Mueller M, Kipngetich S, O'keeffe C, Davidson RN
Download

Similar Content
Loading...
Loading...
Loading...
Abstract
A new rK39 rapid diagnostic dipstick test (DiaMed-IT-Leish) was compared with aspiration and a direct agglutination test (DAT) for diagnosis of visceral leishmaniasis (VL) in 201 parasitologically confirmed cases, 133 endemic controls, and in 356 clinical suspects in disease-endemic and -epidemic areas in Sudan. The sensitivity of the rK39 test in parasitologically confirmed VL cases was 90%, whereas the specificity in disease-endemic controls was 99%. The sensitivity of the DAT was 98%. In clinically suspected cases, the sensitivity of the rK39 test was 81% and the specificity was 97%. When compared with the diagnostic protocol based on the DAT and aspiration used by Médecins sans Frontières in epidemic situations, the positive predictive value was 98%, and the negative predictive value was 71%. This rK39 rapid diagnostic test is suitable for screening as well as diagnosis of VL. Further diagnostic work-up of dipstick-negative patients with clinically suspected VL is important. The ease and convenience of the dipstick test will allow decentralization and improved access to care in disease-endemic areas in Sudan.

Countries

Sudan

Subject Area

diagnosticsneglected tropical diseasesleishmaniasis

Languages

English
Published Date
01 Jan 2006
PubMed ID
16407349
Journal
American Journal of Tropical Medicine and Hygiene
Volume | Issue | Pages
Volume 74, Issue 1, Pages 76-80