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Journal Article
|Research

Ebola Virus Disease, Democratic Republic of the Congo, 2014

Nanclares C, Kapetshi J, Lionetto F, de la Rosa O, Muyembe Tamfun JJ, Alia M, Kobinger GP, Bernasconi A
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Abstract
During July-November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.

Countries

Democratic Republic of Congo

Subject Area

Ebola

Languages

English
DOI
10.3201/eid2209.160354
Published Date
01 Sep 2016
Journal
Emerging Infectious Diseases
Volume | Issue | Pages
Volume 22, Issue 9
Issue Date
2016-09-01
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Ebola Virus Disease, Democratic Republic of the Congo, 2014 | Journal Article / Research | MSF Science Portal