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[Long term adherence to HAART in Senegal] | Journal Article / Research | MSF Science Portal
Journal Article
|Research

[Long term adherence to HAART in Senegal]

Bastard M, Fall BK

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Abstract
Adherence is one of the main predictors of antiretroviral treatment success. A governmental initiative was launched in 1998 for HIV-infected patients in Senegal to provide access to highly active antiretroviral therapy (HAART). Adherence measurements, defined as pills taken/pills prescribed, were assessed between November 1999 and June 2010 using a pill count along with a questionnaire for 330 patients. Predictors of adherence and identification of adherence trajectories were explored through latent class mixed model. We also performed a survival analysis using Cox proportional hazard model. Three adherence behaviours were revealed as well as a better adherence for women. A third of patients had a high adherence trajectory over time and a third had an intermediate one. Male gender and low adherence behaviour over time were independently associated with a higher mortality rate. This study shows that an overall good adherence can be obtained in the long term in Senegal, suggests a better adherence for women and points out a large subsample of patients with intermediate level of adherence behaviour who are at risk for developing resistance to antiretroviral drugs.

Countries

Senegal

Languages

English
DOI
10.1007/s13149-014-0346-9
Published Date
10 Mar 2014
PubMed ID
24615434
Journal
Bulletin de la Société de Pathologie Exotique
Volume | Issue | Pages
Volume 107, Issue 4, Pages 241-243
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