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Journal Article > Research

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Merker M, Blin C, Mona S, Duforet-Frebourg N, Lecher S, Willery E, Blum M, Rusch-Gerdes S, Mokrousov I, Aleksic E, Allix-Bequec C, Antierens A, Augustynowicz-Kopec E, Ballif M, Barletta F, Beck HP, Barry CE, Bonnet MMB, Borroni E, Campos-Herrero I, Cirillo DM, Cox HS, Crowe SJ, Crudu V, Diel R, Drobniewski F, Fauville-Dufaux M, Gagneux S, Ghebremichael S, Hanekom M, Hoffner S, Jiao WW, Kalon S, Kohl TA, Kontsevaya I, Lillebæk T, Maeda S, Nikolayevskyy V, Rasmussen M, Rastogi N, Samper S, Sanchez-Padilla E, Savic B, Shamputa IC, Shen A, Sng LH, Stakenas P, Toit K, Varaine FFV, Vukovic D, Wahl C, Warren RM, Supply P, Niemann S, Wirth T
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Abstract
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
Countries
China
Subject Area
tuberculosis
DOI
10.1038/ng.3195
Published Date
19-Jan-2015
PubMed ID
25599400
Languages
English
Journal
Nature Genetics
Volume / Issue / Pages
Volume 47, Issue 3
Issue Date
19-Jan-2015
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